Pain Flashcards

1
Q

pain is classified into which two categories?

A

nociceptive pain: appropriate response to painful stimulus via intact nervous system

neuropathic pain: inappropriate response caused by dysfunction to nervous system

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2
Q

what are the symtoms of neuropathic pain?

A

shooting/burning sensations

tingling and numbness

allodynia

hyperalgesia

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3
Q

allodynia and hyeralgesia are both innapropriate responses to pain- how do they differ?

A

allodynia: pain in response to stimulus not usually painful i.e. light touch
hyperalgesia: inc in pain response w lowered pain threshold to stimulus that is usually painful i.e. pinprick

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4
Q

what are causes of neuropathic pain?

A

spinal cord injury

MS

stroke

diabetic neuropathy

trigeminal neuralgia

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5
Q

how is neuropathic pain managed?

A

amitriptyline

duloxetine

gabapentin

pregabalin

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6
Q

can standard drugs used in management of neuropathic pain be given for trigeminal neuralgia?

A

No- carbamazepine first line in trigeminal neuralgia

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7
Q

what class of drug is amitriptyline?

A

tricylcic antidepressant

inhibits neuronal reuptake of noradrenaline and serotonin

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8
Q

what is the MoA of duloxetine?

A

inhibits reuptake of serotonin and noradrenaline

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9
Q

which drug used in management of neuropathic pain primarily works by inhibiting high-voltage activated presynaptic Ca2+ channels?

A

gabapentin

pregabalin

(GABA analogue)

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10
Q

which is complex regional pain?

A

chronic condition cuasing neuropathic pain usually affecting the arm or leg

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11
Q

what can precipitate complex regional pain?

A

srugery or minor injury

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12
Q

how is complex regional pain managed?

A

physiotherapy

amitriptyline

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13
Q

neuropathic pain most commonly occurs due to lesions in which area of the brain?

A

thalamic lesions

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14
Q

central post stroke pain occurs in how many stroke patients?

A

10%

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15
Q

how does central post-stroke pain present?

A

rapidly improving hemiplegia w paraesthesia followed by allodynia w abnormal pain sensations

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