PATHOMA- JOINTS Flashcards Preview

BL/DD USMLE and Basics > PATHOMA- JOINTS > Flashcards

Flashcards in PATHOMA- JOINTS Deck (24)
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1
Q

Chronic, systemic, autoimmune disorder
Affects mostly middle aged women
HLA-DR4

A

RA

2
Q

Halmarks of RA

A

synovitis with pannus formation
destruction of cartilage
possible osteopenia

3
Q

Pannus and it’s problems

A
thickening of the synovium 
leads to joint space narrowing 
loss of cartilage 
joint deviations
ankalyzing
4
Q

Clinical picture of RA

A

Morning stiffness- better with activity
symmetric joint involvement
DIPs are spared

may have: lymphandopathy, interstitial lung fibrosis

5
Q

Lab findings of RA

A

RF
inc. neuts and protein in synovial fluid
anemia of chronic disease

6
Q

No RF
Axial skelto
HLA B27

A

seronegative spondyloarthropathy

No RF (seronegative) 
Axial skelton (spondylo)
7
Q

seronegative spondyloarthropathy presentation

A
Usually in males
presents as low back pain
vertebra may fuse
uveitis 
high risk for anyrism
8
Q

Conjunctivitis
urethritis
arthritis
onset after GI/Chlamydia infcetion

A

Reiter syndrome- seronegative spondyloarthropathy

Can’t see, can’t pee, can’t climb a tree

9
Q

Reiter syndrome clinical picture

A

10% w/psoriasis
axial/perf joint. Affects DIPs
“sausage digits”

10
Q

Caused in young adults Gonorrhea
in Adults/Kids by S. Aureas

usually single, warm joint with systemic symptoms

A

Infections Arthritis

11
Q

Deposition of MSU crystals in the tissue

due to hyperuricemia

A

Gout

12
Q

hyperuricemia causes

A

increased production

decreased removal

13
Q

Unknown cause of hyperuricemia

usually in adult males

A

Primary Gout

14
Q

Secondary causes of gout

A

leukemia
MPD
Lesh Nynn
Renal insufic

15
Q

painful arthritis of great toe
crystals activate neurtophils
Triggers are ETOH and meat

A

Acute Gout

16
Q

Tophi

Renal Failure

A

Chronic gout

17
Q

Tophi are

A

uric acid crystals in soft tissue or joints

may have fibrosis

18
Q

Renal Failure from chronic gout is caused by

A

Uric acid deposits in the kidney

19
Q

Gout Labs

A

hyperglycemia

yellow needle shaped crystals

20
Q

______ resembles gout

A

pseudogout

21
Q

Dermatomyositis

A

proximal muscle weakness
malar rash
gortons lesions
helitrope rash

22
Q

Dermatomyositis lab findings

A

inc. CPK
+ana w/ Anti-Jo1
perimysial inflamation

23
Q

Polymyositis vs Dermatomyositis

A

no skin findings

invades endomysium

24
Q

Lipoma

A

tumor of the adipose tissue