Peripheral Nerve disease

Question 1

Flu like illness followed by:
ASCENDING paralysis
-rapid onset weakness
-elevation of CSF protein
-immune mediated demyelination
-usually resolves with time

Answer 1

Guillain-Barre Syndrome

Question 2

T-Cells and Macrophages cause segmental demyelination

remyelination follows

Answer 2

Guillain-Barre Syndrome

Question 3

Slowly progressive infection of skin and nerves

• caused by Mycobacterium________.
• transmitetd through resp droplets
• endemic to poor tropical countries
• causes disabling deformities

Answer 3

Leprosy (Hansen’s disease)

Question 4

Two forms of Leprosy:

Answer 4

Tuberculoid

• less severe
• Dry, scaly, skin lesions
• nerve degeneration
• nice T-cell response to the bug, nice granuloma formation

Lepromatous

• more severe
• skin, nerves, eyes, mouth, testes, hands, feet
• immune system doesn’t respond

Question 5

Common viral infx of PNS

• remains dormant in sensory ganglia of cord, brainstem
• reactivation causes painful, vesicular, dermatomal rash

Answer 5

Varicella Zoster virus

Question 6

Hereditary neuropathy

• REPETITIVE demyelination and REMYELINATION
• HIGH ARCHES
• HAMMER TOES
• MUSCLE ATROPHY
• muscle and sensation loss but PAIN in tact

Answer 6

Charcot-Marie-Tooth disease

also called

Hereditary Motor and Sensory Neuropathy Type 1

Question 7

VERY common acquired metabolic/toxic neuropathy

• symmetric sensory loss
• STOCKING and GLOVE distribution

Answer 7

Diabetic neuropathy

Question 8

Two types of neuropathy associated with malignancies:

Answer 8

Mononeuropathy

Polyneuropathy

Question 9

Differentiate malignancy associated mononeuropathy from polyneuropathy:

Answer 9

Mono: tumor presses on nerve

Poly: PARANEOPLASTIC effect–not a direct result of the mass itself
-sx often present remotely before tumor is found