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Flashcards in Peripheral neuropathy Deck (42):
1

What is Charcot-Marie Tooth disease

A herditary sensorimotor disorder HSMD
chronic demyelinating disorder of the PNS
Presents in 20s

2

Features of Charcot Marie Tooth

Distal muscle wasting and weakness
Champagne bottle appearance
pes cavus
absent reflexes
loss of sensation
calf muscle atrophy

3

What is Guillain Barre syndrome (GBS)

an acute demyelinating disorder of the PNS

4

Features of GBS

pain very common
acute <4 weeks
symmetrical progressive sensorimotor paralysis
areflexia - lose reflexes
associated with post infectious state eg campylobacter
off legs

5

What is chronic inflammatory demyelinating polyradiculoneuropathy

acquired demyelinating condition of the PNS

6

what 5 questions should be asked when it comes to identifying peripheral neuropathy disease

1. which nerves are damaged
2. where are they damaged
3. how are they damaged
4. why are they damaged
5. how to manage this

7

PNS includes ANS, true or false

true

8

modality and function of motor nerves

Aa
muscle control

9

symptoms of damage to motor nerves

muscle weakness and wasting
unsteadiness
reduced power

10

are reflexes absent or present with motor neuron damage

absent

11

is sensation preserved or diminished in motor neuron damage

preserved

12

modality and function of sensory nerves

Aa / AB
fine touch and proprioception

13

symptoms of damage to sensory nerves

reduced vibration and proprioception

14

is power preserved or diminished in sensory neuron damage

preserved

15

are reflexes absent or present with sensory neuron damage

absent

16

modality and function of small fibres

A delta / C
pain and temperature sensation

17

symptoms of small fibre damage

reduced pain and temperature sensation

18

is power preserved or diminished in small fibre damage

preserved

19

are reflexes present or absent in small fibre damage

present

20

modality and function of autonomic nerves

A delta / C
HR, BP, sweating, gut

21

is power preserved in autonomic nerve damage

yes

22

is sensation preserved in autonomic nerve damage

yes

23

are reflexes present in autonomic nerve damage

yes

24

what is pseudoathetosis

large fibre sensory neuropathy with damaged joint position sense

25

what is radiculopathy

damage to the nerve roots

26

what is plexopathy

damage to the plexus

27

what is peripheral neuropathy

damage to the nerves distal to plexus

28

what are the types of peripheral neuropathy

mononeuropathy
mononeuritis multiplex
length dependent peripheral neuropathy

29

give examples of mononeuropathy

carpal tunnel syndrome
cubital tunnel syndrome
common fibular nerve palsy

30

what is mononeuritis multiplex

painful, patchy distribution
affects more than 2 isolated nerve areas

31

is mononeuritis multiplex symmetrical

NO
does not have rules of symmetry

32

in which conditions in mononeuritis multiplex seen

DM
vasculitis
SLE
amyloidosis

33

describe distribution of length dependent peripheral neuropathy

glove and stocking distribution
symmetrical
weakness +/or sensory loss

34

how can nerves be damaged

axonal loss
peripheral nerve demyelination

35

how can peripheral demyelination be classified

acute
chronic

36

examples of acute peripheral demyelinating disease and what is the timescale

Guillain Barré syndrome
Acute Inflammatory Demyelinating Polyradiculoneuropathy AIDP
days - weeks

37

examples of chronic peripheral demyelinating disease and what is the timescale

Hereditary Sensory Motor neuropathy HSMN aka Charcot Marie Tooth disease
Chronic Inflammatory Demyelinating Polyradiculoneuropathy CIDP
months - years

38

management of GBS

IVIG +/or plasma exchange

39

causes of axonal neuropathies

idiopathic
vasculitic
paraneoplastic
infections
drugs/toxins
metabolic

40

causes of autonomic neuropathies

DM
amyloidosis
hereditary
Guillain Barré
porphyrias

41

what is the ABCDEE of peripheral neuropathies

Alcohol
B12 / folate deficiency
Cancer / CKD
Diabetes
Every vasculitis
Especially ANCA and RA

42

which drugs can cause peripheral neuropathy

phenytoin
chemotherapy - cisplatin/vincristine
alcohol
amiodarone