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Flashcards in Pharm 1 Deck (24)
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2
Q

Relates the amount of drug in the body to the plasma concentration

A

Volume of distribution (VD)

3
Q

Plasma concentration of a drug at a given time

A

Cp

4
Q

The ratio of the rate of elimination of a drug to its plasma concentration

A

Clearance (CL)

5
Q

The elimination of drug that occurs before it reaches the systemic circulation

A

First pass effect

6
Q

The fraction of administered dose of a drug that reaches systemic circulation

A

Bioavailability (F)

7
Q

When the rate of drug input equals the rate of drug elimination

A

Steady state

8
Q

Different steps of Phase I

A

Hydrolysis, oxidation, reduction

That 1 is a HOR

9
Q

Products of Phase II conjugation

A

Glucuronate, acetic acid, and glutathione sulfate

GAS - glucuronidation, acetylation, sulfation

10
Q

Constant percentage of substrate metabolized per unit time

A

First order kinetics

11
Q

Drug elimination with a constant amount metabolized regardless of drug concentration

A

Zero order kinetics

12
Q

Target plasma concentration x (volume of distribution / bioavailability)

A

Loading dose (Cp*(Vd/F))

13
Q

Concentration in the plasma x (clearance / bioavailability)

A

Maintenance dose (Cp*(CL/F))

14
Q

Strength of interaction between drug and its receptor

A

Affinity

15
Q

Selectivity of a drug for its receptor

A

Specificity

16
Q

Amount of drug necessary to elicit a biologic effect

A

Potency

17
Q

Ability of a drug to produce 100% of the maximum response regardless of the potency

A

Full agonist

18
Q

Ability to produce less than 100% of the response

A

Partial agonist

19
Q

Ability to bind reversibly to the same site as the drug and without activating the effector system

A

Competitive antagonist

20
Q

Ability to bind to either the same or different site as the drug

A

Noncompetitive antagonist

21
Q

MOA utilizes ligand gated ion channels

A

Benzodiazepines and calcium channel blockers

22
Q

Median effective dose required for an effect in 50% of the population

A

ED50

23
Q

Median toxic dose required for a toxic effect in 50% of the population

A

TD50

24
Q

Window between therapeutic effect and toxic effect

A

Therapeutic index

25
Q

Drug with a high margin of safety

A

High therapeutic index