Pharm Antifungal II Flashcards
1
Q
*Fluconazole Clearance and Bioavailability
A
- RENAL
- Good (90%)
2
Q
Fluconazole CSF access
A
-Good
3
Q
Fluconazole CYP450 inhibition
A
-Weak
4
Q
*Intraconazole Clearance and bioavailability
A
- POOR (requires acid)
- Hepatic
5
Q
*Intraconazole CSF access
A
-POOR
6
Q
*Intraconazole/ Verconazole CYP450 inhibition
A
-STRONG (drug interactions)
7
Q
Voriconazol Clearance and Bioavailability
A
- Hepatic
- Good
8
Q
*Amphotericin toxicity
A
-NEPHROTOXICITY, direct damage to distal tubule
9
Q
*Amphotericin uses
A
- Mucormycosis (zygomycosis-tornado victims)
- CRYPTOCOCCUS: USED WITH 5-FU
10
Q
*Caspofungin
A
Refer to First Aid p. 214
11
Q
*Ketoconazole ADR
A
-GYNEO, DECREASE LABIDO
