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Flashcards in Pharm of Substance Abuse Deck (23)
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1
Q

Opium

A

fluid obtained from the poppy plant

2
Q

Opiate

A

substance derived from opium

3
Q

opiod

A

substance with morphine-like actions; synthetic or semi-synthetic

4
Q

heroin is a

A

pro-drug–>6MAM–>MS
not bioavailable
rapidly penetrates BBB

5
Q

Buprenorphin

A
partial opioid agonist-ceiling effect
low abuse potential
lower level physical dependence
less opioid effect as compared to methadone
safety in overdose quantities
6
Q

suboxone has

A

poor bioavailability- sublingual

7
Q

affinity

A

strength with which a drug physically binds to a receptor

8
Q

Buprenorphine’s affinity

A

very strong, will displace full agonists like heroin or methadone

NOT the same as receptor activation

9
Q

dissociation

A

speed (slow or fast) of disengagement or uncoupling of a drug from the receptor

10
Q

Bu’s dissociation

A

slow- stays on for long time and blocks heroin/methadone’s action

11
Q

treatment for opiate overdose

A

narcan

12
Q

classic triad of oopiate overdose

A

miosis
coma
resp depression

13
Q

early opiate withdrawal

A
lacrimination
yawning
rhinorhea
sweating
anxiety/doom
14
Q

middle phase opiate withdrawal

A
restless sleep
dilated pupils
anorexia
gooseflesh
irritability
tremor
15
Q

late phase opiate withdrawal

A
increase in HR and BP
nausea, vomiting,
ab cramps
depression
weakness
bone pain
16
Q

cocaine mech

A

blocks DA reuptake transported on presyn membrane –>therefore, increasing synaptic dopamine

17
Q

amphetamine mech

A

enter DA neurons via reuptake transporters and interact intracellularly to release DA into presyn terminal

18
Q

what does cocaine do

A

CNS stimulation
adrenergic effects
vasoconstrictive

19
Q

prolonged use of cocaine

A

neuroadaptation- dec DAT dec Dop R

pulmonary effects from smoking

20
Q

meth at high doses

A

hypomania
grandiosity
extreme insomnia
irritability

21
Q

chronic MA leads to

A

reduction in DAT which leads to depletion of DA in presyn temrinas

22
Q

crystal meth wtihdrawal

A

protracted abstinence syndrome

-depression, irritability, suicidal ideation

23
Q

marijuana gets deposited

A

in fat tissue because lipid soluble