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Flashcards in Pharmacokinetics Deck (18)
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1
Q

Thiazides

A

Compete with uric acid for elemination

2
Q

Na nitroprusside

A
Toxic oral (hydrolised to cyanide)
IV short half life (give in continuous infusion)
3
Q

Labetalol, nicardipine

A

Long half life, precludes rapid titration

4
Q

ACEI

A

Taken on empty stomach

5
Q

Digoxin

A

Very low therapeutic index
Long half life (36 hrs)
Eliminated by kidney> dose adjustment wz CrCl
Large VOD, accumulates in muscles> day off

6
Q

Organic nitrates

A
  • Onset of action: nitroglycerin» isosorbide dinitrate» isosorbide mononitrate
  • First-pass metabolism of nitroglycerin» sublingual or transdermal patch
  • Nitrate- free intervals to avoid tolerance
7
Q

Antipsychotics available as long acting injections

A

Fluphenazine, haloperidol, resperidone, olanzapine

8
Q

Valproic acid

A

90% bound to plasma proteins

9
Q

Levodopa

A
  • Take on empty stomach
  • Crosses BBB, converted to dopamine (prodrug)
  • Decarboxylation in the periphery leads to SE
  • Short half life» fluctuations in conc., on-off phenomenon
10
Q

Selegiline

A

Metabolized to amphetamine» insomnia

11
Q

Phenytoin

A

Elemination: saturation kinetics (zero order)

30 min. Before or after food

12
Q

SSRI wz longest half life

A

Fluoxetine, available as sustained release once daily preparation

13
Q

SSRI that are CYP inhibitors

A

Fluoxetine, paroxetine

14
Q

SSRI

A

Dose adjustment wz hepatic impairment

15
Q

Duloxetine

A

Absorption delayed with food

16
Q

Incretin analogs

A

Liraglutide: once daily (bec. Long half life)
Exenatide: twice daily
Exenatide LAR: once weekly

17
Q

Levothyroxin

A

On empty stomach, in the morning

18
Q

Fexofenadine, loratadine

A

Take on empty stomach