Pharmacokinetics - Drug Absorption Flashcards Preview

MS1 - Disease & Defense > Pharmacokinetics - Drug Absorption > Flashcards

Flashcards in Pharmacokinetics - Drug Absorption Deck (10)
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1
Q

List the four factors that affect drug absorption.

A

Molecular size; lipid solubility; ionization; and concentration gradient.

2
Q

The most common method of drug absorption is ______.

A

lipid diffusion through the membrane

3
Q

Bioavailability is also called _______.

A

extent of absorption

4
Q

F (fraction bioavailable) = _____.

A

(AUC route) / (AUC iv)

5
Q

First pass effect is best described as ______.

A

the hepatic or gastric metabolism of a drug prior to entry in to the systemic circulation

6
Q

Rate of drug absorption can be decreased by ________.

A

coating pills in enteric products

7
Q

A generic product is bioequivalent to a brand product if _____ are within set limits.

A

the rate (estimated by Cp and Tmax) and extent (bioavailable portion)

8
Q

Drugs that are _______ have high bioavailability.

A

hydrophobic but stable in aqueous solutions

9
Q

The most bioavailable and fast route is ___.

A

IV

10
Q

Does transdermal or dermal absorb systemically?

A

Transdermal

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