Pharmacokinetics - Drug Metabolism and Excretion Flashcards Preview

MS1 - Disease & Defense > Pharmacokinetics - Drug Metabolism and Excretion > Flashcards

Flashcards in Pharmacokinetics - Drug Metabolism and Excretion Deck (11)
Loading flashcards...
1
Q

Which type of metabolism has greater saturability?

A

Phase II

2
Q

What two substrates are needed for phase I metabolism?

A

Molecular oxygen and NADPH

3
Q

Which type of metabolism is more inducible?

A

Phase I (alcoholics induce CYP2E1)

4
Q

Zero-order kinetics are displayed in reactions ______.

A

that react a constant amount per time (regardless of change in concentration).

5
Q

______ causes decreased clearance of Lipitor.

A

Erythromycin

6
Q

_______ is an enzyme inducer.

A

Phenobarbital

7
Q

Antifungal agents (drugs ending in -azole) are typically ______.

A

enzyme inhibitors

8
Q

Rifampin increases the clearance of _______.

A

oral contraceptives

9
Q

Early neonatal levels of ______ enzymes are 50% - 70% of adult levels.

A

phase I

10
Q

Warfarin targets ________.

A

vitamin K reductase

11
Q

Older people have decreased ______ metabolism.

A

phase I

Decks in MS1 - Disease & Defense Class (59):