Pharmacologic Actions of Drugs Used in the Treatment of Shock Syndromes Flashcards Preview

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Flashcards in Pharmacologic Actions of Drugs Used in the Treatment of Shock Syndromes Deck (10)
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1
Q

Hypovolemic
Cardiogenic
Obstructive shock

A

Loss of blood or fluid leads ot low preload and low CO

Loss of function leads to low output

Extracardiac compromoise of blood flow through heart elads to low CO

2
Q

Septic

A

Maldistribution of BF (arterial vasodilation with reduced systemic sreisstance)

Low preload due to neodilation and cpaillary leakage of fluid…heart compensates by inc inotropy and HR

Inadequate cardiac function superveneces

3
Q

Positive inotropic agents

A

Dobutamine
Dopamine
Epineprhine
Norepineprhine

Inc CO through cAMP

4
Q

Vasoconstrictos

A

Dopamine
Norepineprhine
Epineprhine

Vascular smooth muscle contractio nand inc in TPR and BP

IP3 mediated

5
Q

Vasopressin

A

Induces IP3 mediated vasoconstriction and inc in TPR and BP

6
Q

Dopamine

A

DA1 - renal vasodilation…maintain renal perfusion in advanced HF or cardiogenic shcok

Beta 1 - pos inotropic would inc CO and be useful in cardiogenic shokc…limitedb y tachycardia

Alpha 1 - vasoconstriction not beneficial in heart failure but could be of benefit in vasodilatory shock syndromes where there is a dec in vascular resistance (think septic shock)

7
Q

Dobutamine

A

Beta 1 - pos intorptic…inc CO in cardiogenic

Alpha 1 - vasoconstrcition

Beta 2 - vasodilation

Overall effect is vry modest degree of vasodilation

8
Q

Epineprhine

A

Beta1 - inotropic..inc CO in cardiogenic

Beta 2 - vasodilation

Alpha 1 - vasoconstriction

Inc in PVR from alpha would inc BP so would help where dec in vascular resistance - like septic shock

9
Q

Norepineprhine

A

Beta 1 - CO

Alpha 1 - vasoconstrction…good for septic shcok

10
Q

AVP

A

Vasoconstriction and inc BP in vasodilatory types of shcok such as sepsis