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Flashcards in Pharmacology Deck (16)
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1
Q

List two 1st generation cephalosporins

A
  1. Cefazolin
  2. Cephalexin
2
Q

List the characteristics of cefazolin

A
  1. Very good for staph & Strep coverage, OK for community GNR
  2. Perfect agent for skin infections, also for community UTIs
  3. Only administered IV
3
Q

List the characteristics of cephalexin

A
  1. Very good for staph & Strep coverage, OK for community GNR
  2. Perfect agen for skin infections, also for community UTIs
  3. Only administered orally
4
Q

List 4 2nd generation cephalosporins

A
  1. Cefuroxime
  2. Cefamandole
  3. Cefotetan
  4. Cefoxitin
5
Q

List the characterisrics of Cefuroxime

A
6
Q

List the characteristics of Cefamandole

A
  1. 2nd generation cephalosporin
  2. Contains a methylthiotetrazole (MTT) side chain
  3. MTT interfers with vitamin K-dependent y-carboxylation →
7
Q

List the characteristics of cefotetan

A
8
Q

List the characteristics of cefoxitin

A
  1. 2nd generation cephalosporin
  2. Loses Staph coverage, good community GNR, but the key is outstanding anaerobic coverage
  3. Lacks MTT moiety
9
Q

List 5 3rd generation cephalosporins

A
  1. Ceftriaxone
  2. Cefotaxime
  3. Ceftizoxime
  4. Cefixime
  5. Cefepime
10
Q

List the characteristics of Ceftriaxone

A
11
Q

List the characteristics of Cefotaxime

A
  1. 3rd generation cephalosporin
  2. Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
  3. Doses 3X/day (8 hr effect)
12
Q

List the characteristics of Ceftizoxime

A
  1. 3rd generation cephalosporin
  2. Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
  3. Doses 3X/day (8 hr effect)
  4. Expanded anaerobic coverage
13
Q

List the characteristics of Ceftazidime

A
14
Q

List the characteristics of Cefixime

A
15
Q

Name an example of 4th generation cephalosporin

A

Cefepime

16
Q

List the characteristics of Cefepime

A
  1. 4th generation cephalosporin
  2. Remarkably broad spectrum, excellent Staph, Strep, community and nosocomial GNR