Pharmacology of Arthritis Flashcards Preview

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Flashcards in Pharmacology of Arthritis Deck (14)
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1
Q

What are the main clinical side effects of NSAIDs?

A
GI dysfunction
Renal impairment
Increased CV risk
Fluid retention
Wheeze
Rash
2
Q

Which new drug is used as an alternative to NSAIDs?

A

Cox-2 inhibitors

3
Q

What are the main clinical side effects of methotrexate?

A
Teratogenic 
Leucopaenia/ thrombocytopaenia 
Hepatitis/ cirrhosis
Pneumonitis
Rash/ mouth ulcers
Nausea
Diarrhoea
4
Q

How long before conception should DMARDs be stopped?

A

3 months

5
Q

What are the main clinical side effects of leflunomide?

A

Hepatotoxicity
Hypertension
Teratogenic

6
Q

What are the main clinical side effects of sulfasaline?

A

Low sperm count
Insomnia
Depression
Yellow body fluids

7
Q

What is the main clinical side effect of hydroxychloroquine?

A

Irreversible retinopathy

8
Q

Which DMARDs are safe to use in pregnancy?

A

Sulfasaline

HCQ

9
Q

What are the main clinical side effects of biological agents?

A

Risk of infection especially TB
Malignancy risk?
CI in pulmonary fibrosis, HF

10
Q

What type of drug is allopurinol?

A

Xanthine oxidase inhibitor (stops purine being converted into uric acid)

11
Q

What are the main clinical side effects of allopurinol?

A

Rash
Renal disease
Bone marrow aplasia

12
Q

What are alternative medications that can be prescribed in the prophylaxis of gout?

A

Febuxostat

Uricosurics

13
Q

List the main clinical side effects of steroids

A
Weight gain
Muscle wasting
Skin atrophy
Osteoporosis
DM
Hypertension
Cataracts/ glaucoma
Fluid retention
Adrenal suppresion
|mmunosuppression
AVN of femoral head
14
Q

What is the main clinical consideration for prescribing steroids in the elderly?

A

Osteoporosis prophylaxis