Phosphodisterase Type 5 (PDE5) Inhibitors Flashcards Preview

3: Drugs for Clinical Medicine > Phosphodisterase Type 5 (PDE5) Inhibitors > Flashcards

Flashcards in Phosphodisterase Type 5 (PDE5) Inhibitors Deck (7)
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1
Q

Give 3 PDE5 inhibitors

A
  • Sildenafil
  • Vardenafil
  • Tadalafil
2
Q

What is the mechanism of action of PDE5 inhibitors?

A

Inhibit phosphodiesterase type 5

3
Q

What does PDE5 do?

A

Breaks down cGMP

4
Q

What does cGMP do?

A

Causes relaxation and vasodilatation of the peripheral arteries, and increased blood flow to the penis, resulting in penile engorgement

5
Q

Where is cGMP found?

A

Found naturally in the lungs, and is produced following sexual stimulation in the corpus cavernosum of the penis

6
Q

How does the inhibition of PDE5 lead to the effects of PDE5 inhibitors?

A

Inhibition of cGMP breakdown will increase cGMP levels, and this will relieve pulmonary hypertension and improve the ability of a male to have an erection

7
Q

What are the routes of delivery of PDE5 inhibitors?

A
  • PO

- IV