Platinating Drugs Flashcards
is cisplatin an alkylating agent
no, its “alkylating-like”
what chemical structure does cisplatin contain
platinum atom
2 amines
2 chlorides
what form is cisplatin administered as
IV- oral is ineffective
does cisplatin penetrate the CNS
no
where are high concentrations is cisplatin found
kidneys
liver
intestines
testes
what is the prominent dose limiting side effect of cisplatin
renal toxicity
decreased GFR and renal tubular dysfunction produced by cisplatin may begin how many days after initiating treatment. alone with increase BUN, cr, proteinuria, and hyperuricemia
3-5 days
what electrolyte imbalance is associated with cisplatin
magnesium wasting defect
what 2 things does the hypo magnesium may predispose the patient to
cardiac dysrhythmias
decrease neuromuscular blocking drugs
other than renal toxicity- what is cisplatin known to produce
ototoxicity- manifesting as tinnitus and hearing loss in the high-frequency range.
almost all patients experience this side effect from cisplatin which prophylactics can help be extremely effective
highly emetogenic with marked nausea and vomiting.
what are the allergic reactions seen with cisplatin minutes after injection
facial edema
bronchoconstriction
tachycardia
hypotension
does cisplatin have myelosuppression
Yes! transient leukopenia and thrombocytopenia.
