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Oncology Exam 1 > Platinum Compounds > Flashcards

Flashcards in Platinum Compounds Deck (13)
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1
Q

Platinum Compound Indications

A

Testicular, ovarian, mesothelioma, head, neck, SCLC, and bladder cancers

2
Q

Changes in agent development

A

o Introduced bulky groups because with cisplatin, the chloride groups are replaced with water very fast and they stay in the renal system for a very long time (renal toxicity) → alkylating agent really quickly
o With the bulky groups carboplatin and oxaliplatin are converted much slower and don’t have the renal toxicity

3
Q

Naming of platinum compounds

A

 Cis comes from the chlorides being on the same side

 Transplatin is not a good anti-cancer drug because the chlorides are on opposite side and it doesn’t bind well

4
Q

Most common cross linking with platinum compounds

A

G-G intRAstrand 60%

A-G intRAstrand 30%

5
Q

Cisplatin Toxicity

A

Nephrotoxicity
Ototoxicity (hearing loss)
N/V

6
Q

Carboplatin Structure

A

Substituted chloride = diminished nephrotoxicity

7
Q

Carboplatin Toxicity

A

Myelosuppression and N/V

8
Q

Oxaliplatin Structure

A

Bulkier adducts and more hydrophobic

9
Q

Oxaliplatin does what kinds of crosslinking

A

Does interstrand, intrastrand and DNA-protein crosslinking

10
Q

Problem with oxaliplatin’s crosslinking?

A

Problem with protein involvement is that the proteins that recognize damaged DNA may become activated

11
Q

Oxaliplatin toxicity

A

Neurotoxicity

N/V

12
Q

Platinum Compound Resistance

A

Same as alkylating with glutathione

13
Q

Prevention of platinum compound induced AE

A

MESNA (2-mercaptoethane sulfonate)
Sodium thiosulfate
Amifostine
- Mainly with cisplatin and carboplatin