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Semester 1- MGD > Protein Folding > Flashcards

Flashcards in Protein Folding Deck (19)
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1
Q

What is the secondary sequence of a protein?

A

Local spacial arrangement (eg. a-helix)

2
Q

What is the tertiary sequence of a protein?

A

3D arrangement of all atoms

3
Q

What is the quaternary sequence of a protein?

A

3D arrangement of protein subunits

4
Q

What type of bonds hold the primary sequence together?

A

Covalent bonds

5
Q

How long is each turn (pitch) of the alpha helix coil?

A

0.54nm

6
Q

How many amino acids are in each pitch?

A

3.6

7
Q

What type of bonds form between the chain links to maintain the alpha helix structure?

A

Hydrogen bonds

8
Q

Name two amino acids that act as alpha-helix breakers

A

Pro- makes rotation impossible

Gly- the small R group works better in other structures

9
Q

What does a B-strand look like?

A

The chain is fully extended

10
Q

What is the distance between adjacent amino acids?

A

0.35nm

11
Q

How do the R groups lie in a B-strand?

A

Alternate on opposite sides of the chain

12
Q

What happens when multiple B-strands lie anti-parallel to each other?

A

A B-sheet forms

13
Q

Name 3 functions of a fibrous protein

A

Support, shape, protection

14
Q

Name 2 functions of a globular protein

A

Catalysis, Regulation

15
Q

What is a protein domain?

A

Part of the polypeptide chain that folds into a distinct shape with often a specific functional role.

16
Q

Give 2 examples of proteins with quaternary structures

A

Ribosome

Haemoglobin

17
Q

What is protein denaturation? Give 2 causes

A

The forces break within a protein and the structure cannot be maintained. It can be caused by heat, pH changes, detergents

18
Q

What is an amyloid fibre?

A

A misfolded, insoluble form of a normally soluble protein.

19
Q

What is the primary sequence of a protein?

A

The linear amino acid sequence