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Derm > Psoriasis > Flashcards

Psoriasis Flashcards

0
Q

top causes of death with psoriasis

A

CVD> infection > cancer

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1
Q

papulosquamous disease

A

inflammatory disorder characterized by scaly papules and plaques
–>scaly (abnormally thick, flaky startum corneum) +/- crust (dried blood and serum)

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2
Q

what is the believed etiology of psoriasis

A

abnormal t cell function and communication (specifically Th17 and IL23)

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3
Q

physical presentation of psoriasis

A

scalp, groin, extensor surfaces

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4
Q

other organs psoriasis involves

A

nails: pitting + pil spotting
joints: Rh- arthritis

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5
Q

Auspitz sign

A

plaque with silvery scale that pinpoint bleeds on removal

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6
Q

4 clinical subtypes of psoriasis

A

plaque
guttate
erythrodermic
pustula

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7
Q

plaque psoriasis

A

raised, red, sclay

elbows, knees, butt crack (80% of cases)

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8
Q

guttate psoriasis

A

small dot like lesions usually secondary to staph superantigen

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9
Q

tx of guttate psoriasis

A

penicillin

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10
Q

erythrodermic psoriasis

A

intense redness, inflammatory scaling, loose heat and fluids

deep dermal redness

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11
Q

pustual psoriasis

A

pus-filled lesion with some scaling; often localized to plams and soles
–appear brown, but still surrounded by ham lesions

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12
Q

pattern erythrodermic subtype follows

A

progressive; knees up

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13
Q

inverse psoriasis

A

targets skin fold areas INSTEAD of extensor surfaces

increases with topical steroids which promote yeast growth

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14
Q

tx of psoriasis

A

topicals: for mild-moderate psoriasis- coal tar, anthral, topical steroid, vitD
photorx: moderate severe or localized tough plaque: UVB, PUVA (psoralen + UVA)
systemics
biologics

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15
Q

systemic treatments

A

MTX
cyclosporine
acitretin (retinoid)b

16
Q

biologics

A

anti-t cell therapies
anti-tnfa
new drugs focusing on Th17 and IL17a

17
Q

PASI score

A

scale ranging from 0-72 based on area involved by region and severity of process, want to improve by greater/ 75%

18
Q

seborrheic dermatitis

A

pityrosporum yeast infection which infests sebaceous glands

19
Q

clinical prsesentation of seborrheic dermatitis in adults

A

moist, transparent-tellow greasy scaling papules in ares where seb glands are maximum

tends to have a chronic course with remissions and exacerbations

20
Q

seborrheic derm is similar to

A

rosacea, but rosacea has scales

21
Q

where do you typically find seborrheic dermatitis

A

scalp margins, central face, presternal ares, eyebrows, face and eyelashes, nasolabial folds and paranasla skin, external ear canals

22
Q

seborrheic dermatitis in infants

A

“cradle cap”–minimal underlying redness that usually resolves sponatenously–>need to get it off!

23
Q

pityriasis rosea

A

common, self limited, usually post viral xanthem

24
Q

age of pityriasis rosea

A

10-35 years

25
Q

clinical presentation of pityriasis rosea

A 
hearld patch (first lesion, salmon colored with trailing scale)
1-2 weeks later: explosive, x mas tress dist of smaller lesions that resolve without scar
26
Q

PR follows

A

URI

27
Q

lichen planus

A

uncommon, inflammatory PSD with unknown etiology

28
Q

what body parts does lichen planus effect

A

skin
nails
hair
mucous membranes

29
Q

clinical presentation of lichen planus

A

itching, intermittent and insatiable
purple, polygonal, pruritic, papules, plaques
wickham’s striae

30
Q

wickham;s striae

A

lacy reticulated

31
Q

koebner phenomenon

A

lesions develop in areas of injury

unique to PSD

32
Q

in 3% of cases, severe oral lichen planus can degenerate to

A

sqaumous cell

33
Q

lichen schelorisis

A

chronic PSD of unknown etio

much more common in women over 60 but can occur at angy age

34
Q

what does lichen sclerosus effect

A

skin and mucosal surfaces

35
Q

skin lesions in lichen clerosus are usually

A

asymptomatic

36
Q

clinical presentation for women in lichen sclerosus

A

women complain of chronic vulvar pruritis, dysuria or dyspareunia (chronic scarring)

37
Q

clinical presenation for men in lichen sclerosus

A

persistent balanitis (swlling of head of penis)–>if untreated can progress to phimosis (inability to retract foreskin and even erectile dysfunction)

38
Q

lichen sclerosus is considered

A

pre-cancerous–squamous cell carcinoma in 3% of lesions

Derm (15 decks)

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