randomisation, blinding and bias Flashcards Preview

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Flashcards in randomisation, blinding and bias Deck (8)
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1
Q

randomisation

A

based on chance alone by which study participant is assigned to either treatment or control group

2
Q

randomisation minimises

A

the difference among groups by equally distributing people with particular characteristics among all trial arms
–> reducing confounding effect

3
Q

randomisation prevents

A

bias associated with patients and investigators expectations

4
Q

blinding

A

refers to keeping study participants, those involved with their management, and those collecting and analysing data unaware of the assigned treatment
–> therefore researchers cant be influenced by known if participant had drug or not

5
Q

bias

A

a process where scientists performing the research influence the results, in order to portray a certain outcome

6
Q

Explain Intention to treat analysis

A

treatment group are analysed as they were intended to be i.e. even if they completed the protocol or not

7
Q

how would a participant be treated if they crossed over to the other arm

A

analysed as they were intended to be

8
Q

why is ITT important

A

maintains composition of treatment groups - reducing the potential for confounding results from an imbalance in baseline characteristics