Rate-Limiting Steps, USMLE Flashcards Preview

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Flashcards in Rate-Limiting Steps, USMLE Deck (19):
1

Rate limiting step for glycogenolysis

Glycogen phosphorylase

2

Rate limiting step for HMP shunt

G6PD

3

Rate limiting step for De novo pyrimidine synthesis

Carbamoyl phosphate synthetase II

4

Rate limiting step for De novo purine synthesis

Glutamine-PRPP aminotransferase

5

Rate limiting step for glycolysis

Phosphofructokinase-1

6

Rate limiting step for Gluconeogenesis

fructose-1,6-bisphosphatase

7

Rate limiting step for TCA cycle (krebb cycle)

Isocitrate dehydrogenase

8

Rate limiting step for glycogen synthesis

glycogen synthase

9

Rate limiting step for Urea cycle/synthesis

carbamoyl phosphate synthetase I (mitochondria)

10

Rate limiting step for Fatty acid synthesis

Acetyl-coA carboxylase (ACC)

11

Rate limiting step for fatty acid oxidation

Carnitine acyltransferase I

12

Rate limiting step for ketogenesis

HMG-coA synthase

13

Rate limiting step for cholesterol synthesis

HMG-CoA reductase

14

Rate limiting step for heme synthesis

Aminolevulinate synthase (ALA synthetase)

15

Rate limiting step for bile acid synthesis

7-alpha-hydroxylase

16

Gluconeogenesis enzyme that is stimulated by cortisol, epinephrine, and glucagon when energy levels from beta oxidation are adequate

Phosphoenolpyruvate carboxykinase

17

Ezyme bridges glycolysis with the tricarboxylic acid cycle and requires co-factors from the electron transport chain (NAD/FAD; If hypoxic = no cofactors --> no ezyme activity)

Pyruvate dehydrogenase ( Pyruvate + co A ---(enzyme used) --> acetyl-co a)

18

Rate-limiting enzyme: Uric acid metabolism

Xanthine oxidase

19

Catecholamine synthesis

Tyrosine hydroxylase