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Flashcards in reactions Deck (18)
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1

Hydroxylation of Lys

2

Hydroxylation of Pro

3

Synthesis of Purine nucleotides (de novo)

Glucose --> 5-phosphoribosyl-amine

4

Synthesis of Purine nucleotides (de novo)

5-phosphoribosyl-amine --> IMP

5

Synthesis of Purine nucleotides (de novo)

IMP --> GMP / AMP

6

Synthesis of Purine nucleotides (de novo)

GMP / AMP --> GTP / ATP

7

Degradation of Purine nucleotides

AMP -> Hypoxanthine

8

Degradation of Purine nucleotides
Hypoxanthine --> Allantoine

9

Degradation of Purine nucleotides

GMP --> Allontoine

10

Synthesis of Pyrimidine nucleotides (de novo)

HCO3- --> Dihydrorotate

11

Synthesis of Pyrimidine nucleotides (de novo)

Dihydroorotate --> UMP

12

Synthesis of Pyrimidine nucleotides (de novo)

UMP --> CTP

13

Degradation of pyrimidine nucleotides

 

14

Resynthesis of Nucleotides (Salvage pathway)

In each nucleotide:

15

Resynthesis of Nucleotides (Salvage pathway)

In Eucaryotes:

16

Resynthesis of Nucleotides (Salvage pathway)

In prokaryotes:

17

Synthesis of Deoxyribonucleotides:

18

Degradation of Deoxyribonucleotides:

Differences compared to the degradation of ribonucleotides:

  • Nucleoside phosphorylase releases deoxy-ribose-1-phosphate from deoxyribonucleosides
  • At purine bases: no differences in steps of degradation
  • At pyrimidine bases: differences in steps of degradation as follows: 
  • Deoxythymidine has one more methyl group, that is why instead of ureidopropioanate ureidoisobutyrate will be produces. The endproduct is instead of beta-alanine, beta-amino-isobutyrate