Renal Cell Cancer Flashcards

1
Q

MC sex?

A

Male

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2
Q

Which type is most common?

A

Clear cell RCC

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3
Q

Classic triad?

A

Hematuria
Abdominal mass
Flank pain

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4
Q

Other symptoms of RCC (not triad)?

A

HTN
Hypercalcemia
Nonspecific symptoms
Paraneoplastic syndrome

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5
Q

RFs ?

A

Smoking
Obesity + loop diuretics
Renal transplant (risk increases 80 TIMES)
Von Hippel Lindau

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6
Q

What does von hippel lindau cause?

A

Angiogenesis and proliferation

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7
Q

Staging?

A

TNM

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8
Q

Imaging?

A

USG
CT
MRI –> best if infiltration of IVC

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9
Q

Management of early stage?

A

SURGERY (only cure!!)

- nephrectomy, ablation,

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10
Q

Adjuvant tx to surgery?

A

NOT BENEFICIAL!!!!

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11
Q

Management of advanced stage?

A

Surgery + systemic tx

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12
Q

Which systemic tx used in advanced stage?

A
Cytokines
Bevacizumab
Sunitinib
Everolimus, temsirolimus
Chemotx (gemcarbo)
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13
Q

Mechnism of everolimus?

A

mTOR inhibitors

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14
Q

Which chemotx in advanced stage?

A

GemCarbo,Gemcis

–> NB CISPLATIN is nephrotoxic!!!!

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15
Q

Where does metastasis go in RCC?

A

Heart
Skin
Urogenital tract

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16
Q

What are Heng criteria?

A
Performance status
Hb
Calcium
Platelets
Neutrophils
17
Q

Side effects of sunitinib?

A

Hypertension
Hand-foot syndrome
Myelosuppression