Renal cell carcinoma Flashcards Preview

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Flashcards in Renal cell carcinoma Deck (14)
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1
Q

what are the most common histological type in RCC

A

Clear cell (75 %)

2
Q

RF for RCC

A

smoking, obesity, htn, loop diuretics, dialysis, aquired cystic disease. renal transplant, analgesics, MEN 40-60 YOA

3
Q

presentation of RCC

A

hematuria, pain, mass.

4
Q

imaging in RCC

A

USG, CT is gold standard in staging. MRI when infiltration of IVC.

5
Q

Staging of RCC

A

TNM

6
Q

VHL mutation on RCC

A

framshift, deletion, promoter methylation.

7
Q

Radical treatment of RCC

A

SURGERY (exam) and have NO benefit of adjuvant therapy

8
Q

what is radical nephrectomy

A

kidney + adrenal + regional LN

9
Q

prognostic factors RCC

A

histolog + cytology, furham grade, nuclear grade, size, necrosis, PS, clinical presentation.

10
Q

where does RCC metastasize

A

heart, skin, subcutanoeus, genitals,

11
Q

systemic treatment in RCC

A

cytokines: HD: IL2, IFN alpha,
VEGF pathway: bevazucimab, iber
mTOR: inhibitors (temsirolimus = in pts with poor prognosis)

12
Q

when to do partial nephrectomy in RCC

A

when cencer is under

13
Q

heng criteria?

A

RCC metatatic disease. poor prognostic factors.

- KPS

14
Q

targeted therapy SE

A

HFS, hypothyroidism. HTN, (treatment with ACEI)