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Flashcards in Respiratory (UW) Deck (34)
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1
Q

Nitroprusside overdose treatment?

A

= cyanide poisoning

so give nitrite+ sulfates+ hydroxocobalamin

2
Q

the c-ANCAs and p-ANCAs have antibodies against who?

A

neutrophils!

“antineutrophil cytoplasmic antibodies”

3
Q

salicylate poisoning timeline?

A

(1) <12 hr= respiratory alkalosis
(2) >12 hr= respiratory alkalosis w/ metabolic acidosis (gap)

so pH will look normalish, w/ decreased PCO2 (more decreased than expected w just metabolic acidosis) and decreased bicarb

4
Q

who releases IFNy

A

TH1

5
Q

Jarisch-Herxheimer Reaction

A

after treatment of spirochete infection– rapid lysis causes infiltration of blood and an innate immune response

6
Q

what does a chest tube pierce?

A
  • serratus anterior
  • intercostal muscles
  • parietal pleura
7
Q

where should thoracocentesis be performed (3 points)
whats the risk of doing it above?
whats the risk of doing it below?

A
T8- midclavicular 
T10- midaxillary 
T12- midscapular 
above- injure lung 
below- injure abdominal contents
8
Q

ingesting rat poison. how do you reverse?

A

= warfarin overdose, bc rat poison has warfarin

- t(x)= FFP

9
Q

people with silicosis have an increased risk of?

A

tuberculosis

b/c silicosis affects macrophage’s phagolysosome ability

10
Q

waxy hyaline membranes of fibrin, necrotic epithelial cells, and edema fluid is consistent with what lung injury

A

ARDS

11
Q

thick bronchial walls, neutrophil infiltrate, mucus? pathologic features of what?

A

chronic bronchitis

12
Q

low DLCO is characteristic of

A

emphysema

13
Q

PE shows what blood chemistry values

A

hypoxemia : low PaO2

respiratory alkalosis: low PaCO2, high pH

14
Q

bronchiectasis infectious origin?

A

Aspergillus

15
Q

CF 508 problem?

A

incorrect post-translational processing of CF causes it to be targetted to proteasome

16
Q

transplant patient + pneumonitis + owl’s eye

A

CMV pneumonitis

17
Q

whats the most effective anti-inflammatory treatment for asthma which can also decrease mucus production

A

glucocorticoids

18
Q

causes of decreased lung compliance (3)

A
  • Left Heart Failure
  • lack of surfactant
  • pulmonary fibrosis
19
Q

secondary bacterial pneumonia
occurs after?
most common culprits?

A
  • after infection with influenza A

- – S. penumo, S. Aureus, H INfluenzae can cause pneumonia

20
Q

lung abcess treatment

A

Clindamycin

21
Q

Cheynes Stokes breathing, what disease?

A

CHF

22
Q

when is airway pressure 0 and intrapleural pressure -5

A

FRC

23
Q

second hand smoke puts kiddos at risk for

A

low birth weight
sudden infant death syndrome
otitis media
asthma

24
Q

what activates eosinophils (ex: in asthma)

A

TH2 cells releasing IL5

25
Q

both PE and high altitude show what blood chemistries?

A

hypoxemia

respiratory alkalosis

26
Q

red thick capsule on mucimarine stain?

A

Cryptococcus Neoformans

27
Q

patients with CF produce sweat with high concentrations of what?

A

Cl

and Na

28
Q

why is it a bad idea to give people with COPD VERY high levels of O2

A

it can increase the V/Q mismatch
increases in oxygen will cause vasodilation and shunt blood to alveolar dead space— causing an increasein physiologic dead space

29
Q

“honeycombing” in lungs

A

Idiopathic pulmonary fibrosis

30
Q

what causes tracheal deviation towards the affected side?

A

lung collapse- ex– main stem bronchus obstruction

31
Q

how does aging affect the lung?

A
  • decrease in chest wall compliance
  • increase in lung compliance
  • total increase in residual volume, decrease in FVC, and the total lung capacity stays the same
32
Q

branching gram positive organisms

A

Nocardia

33
Q

what does obesity do to lungs?

A

restrictive lung disease patterns
you will notice a much lower ERV.. and therefore a lower FRC (ERV+RV)
note that RV stays more or less the same
FEV1, FVC, and TLC may also go down slightly

34
Q

hemosedrin laden macrophages in lungs=

A

“heart failure cells”