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PH 152 > Respiratory Viruses > Flashcards

Respiratory Viruses Flashcards

1
Q

family of influenza virus

A

Orthomyxoviridae

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2
Q

Which influenza type is zoonotic?
A. A
B. B
C. C

A

A

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3
Q 
Which is true?
A. All have 2 surface glycoproteins.
B. All have  segmented genome.
C. All cause human epidemics & pandemics.
D. All have matrix proteins.
A

B

Type C has 1 surface glycoprotein.
Human epidemics c/o Types A & B
Type A - matrix proteins + pandemic

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4
Q

Which specific influenza virus was termed “Spanish flu” in 1918-19?

A

A(H1N1)

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5
Q

Which specific influenza virus was termed “Asian flu” in 1957-58?

A

A(H2N2)

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6
Q

Which specific influenza virus was termed “Hong Kong flu” in 1968-69?

A

A(H3N2)

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7
Q

main mode of transmission of influenza

A

Aerosol

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8
Q

enumerate the protein spikes in influenzae

A

hemagglutinin or “H” spike

neuraminidase or “N” spike

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9
Q 
posttransitional cleavage occurs in:
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

A

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10
Q 
facilitates release of virion
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

B

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11
Q 
promotes fusion
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

A

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12
Q 
prevents aggregation of virus
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

B

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13
Q 
cleaves sialic acid residues of mucus
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

b

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14
Q 
binds to receptor with sialic acid
A. hemagglutinin or "H" spike
B. neuraminidase or "N" spike
C. both
D. neither
A

A

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15
Q

Minor mutations in the hemagglutinin antigen
• Makes prior immunity less effective and ensures that
enough susceptible people are available for the
survival of the virus

identify

A

antigenic drift

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16
Q

Occur when two separate strains of influenza infect

the same cell simultaneously

A

antigenic shift

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17
Q 
may cause pandemics
A. antigenic shift
B. antigenic drift
C. both
D. neighter
A

A

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18
Q 
Which is not a reason for Type B's "non-pandemicity"?
A.There is no known animal reservoir.
B. Antigenic shifts only
C. both
D. neighter
A

B

drift, not shift
shift–>pandemic

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19
Q

Sequence the pathogenesis of influenza:
A. secondary bacterial infection
B. impairment of ciliary clearance
C. inflammation and irritation of respi tract
D. virus binds to ciliated columnar cells
E. shedding of ciliated columnar cells

A

D E B C A

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20
Q 
Croup is a \_\_ complication of influenza in young children.
A. neurologic
B. cardiac
C. gastrointestinal
D. pulmonary
A

D

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21
Q 
Reye's syndrome is a complication of influenza @ \_\_
A. liver
B. CNS
C. lungs
D. A and B
E. B and C
A

D

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22
Q 
Guillan-Barre syndrome is a complication of influenza @ \_\_
A. CNS
B. PNS
C. Both
D. Neither
A

B

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23
Q

antiviral drug that is as effective as vaccine in preventing influenza

A

amantadine

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24
Q

zanamivir and oseltamivir inhibit __

A

sialidase

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25
Q

rimantadine and amantadine work only for type __
A. A
B. B
C. C

A

A

26
Q

enumerate components of flu vaccine

A

A(H1N1)
A(H3N2)
B

27
Q

T or F

The yearly vaccine is the activated type.

A

F

inactivated dapat

28
Q

Why is the interferon important?

A

o Puts the infected cell into an antiviral state to prevent

the attachment or entry of the virus

29
Q

Which is false?
A. IgG and IgA that were produced due to a specific strain will only be protective for that strain only
B. NA antibodies more important because they can neutralize
C. both
D. neither

A

B

HA dapat

30
Q

Mumps has only one serotype. T or F

A

T

31
Q

Type of vaccine used to prevent mumps

A

live attenuated vaccine

32
Q

subfamily of mumps virus

A

paramyxoviruses

33
Q

genus of mumps virus

A

Rubulavirus

34
Q

genus of measles virus

A

Morbilivirus

35
Q

glycoproteins present in pneumovirus subfamily

A

G and F

36
Q

glycoproteins present in morbilivirus genus

A

H and F

37
Q

glycoproteins present in rubula virus & paramyxovirus

A

HN & F

38
Q

Which is true?
A. Mumps virus are shed in the saliva therefore it is infectious even before noticeable symptoms arise.
B. All mumps cases involve swelling.
C. Mumps is zoonotic.
D. Live attenuated vaccine is contraindicated in immunosuppressed patients, but not pregnant women.

A

A

30% of mumps cases: no swelling.
Man: only host.
Contraindications of vaccine: pregnant women & immunosuppressed people.

39
Q

Most common site of growth for mumps

A

salivary gland

40
Q 
Which is not a local invader?
A.corona virus
B.rhinovirus
C.adenovirus
D.measles
A

D

41
Q 
Which is not a systemic invader?
A.polio virus
B.Epstein-Barr virus
C.adenovirus
D.measles
A

C

42
Q 
most common cause of the common cold
A.corona virus
B.rhinovirus
C.adenovirus
D.measles
A

B

43
Q 
False about Parainfluenza virus
A. Spherical or pleomorphic
B. Naked virus
C. Unsegmented genome
D. Negative sense, helical ss RNA
A

B

enveloped dapat

44
Q

False about parainfluenza virus
A.Labile, but survive on surfaces for several hours
B.Resistant to destruction by soap and water, and disinfectants
C.Hemadsorbing virus
D.Antigenically stable

A

B

Susceptible

45
Q

substance responsible for formation of mRNA

and protein synthesis

A

• RNA-dependent RNA polymerase

46
Q

How is parainfluenza virus transmitted?

A

large droplets, aerosols and fomites

47
Q

croup is also known as __

A

acute parainfluenza virus laryngotracheobronchitis

48
Q

sporadic cases are caused by
A. PIV 1
B. PIV 2
C. PIV 3

A

C

49
Q

Which is not a usual diagnostic method for parainfluenza?
A.Antigen Detection in nasopharyngeal secretions
B.Viral culture
C.Serology
D.Animal inoculation
E.DNA Amplification

A

D

50
Q

most sensitive method for detecting parainfluenza

A

E

51
Q 
false about respiratory syncytial virus
A.Enveloped virus
B.Spherical or pleomorphic
C.Single stranded negative sense DNA
D.None of the above
A

C

RNA dapat

52
Q

Enumerate the envelope glycoproteins of RSV. Which determines subgroups?

A

F and G

G determines subgroups

53
Q

Which glycoprotein is in charge of viral attachment?

A

G protein

54
Q

Which glycoprotein is in charge of viral fusion with cell membrane?

A

F protein

55
Q 
Which is not part of RSV pathophysio?
A)Decreased mucin secretion
B)Cell necrosis within mucosa ==>sloughing
C)Obstruction of lumina-debris, mucin
D)Peribronchial lymphocytic infiltration
A

A

increased dapat. kaya magiging mucosal edema

56
Q

__ response in some people is linked to airway hyperreactivity

A

IgE

57
Q

main modes of transmission for RSV?

A

droplets, fingers, fomites

58
Q

all are radiologic features of RSV bronchiolitis except
A.Atelectasis
B.Hypoinflation
C.Streaking
D.Perihilar infiltrates esp. right middle or upper lobes

A

B

hyperinflation dapat

59
Q

cytopathic effect manifestation of RSV

A

multinucleated giant cells

60
Q

IDENTIFY

synthetic guanosine analogue, given as an aerosol,

A

Ribavirin

61
Q

immunoprophylaxis is passive immunization, T or F?

A

T

PH 152 (47 decks)

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