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2MB Musculoskeletal > Rheum. Pharmacology > Flashcards

Rheum. Pharmacology Flashcards

1
Q

Which drugs provide symptom relief in inflammatory arthritis?

A

Paracetamol
NSAIDs
Opiates
Atypical analgesics

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2
Q

Which two groups of drugs are classed as disease-modifying drugs in rheumatology?

A

DMARDs

Biologics

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3
Q

Give examples of DMARDS

A

Methotrexate
Sulphasalazine
Hydroxychloroquine

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4
Q

Give examples of biologics

A

Anti-TNF

Ritixumab

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5
Q

List some analgesic drugs

A

Co-codamol
Tramadol
Amitryptilline
Gabapentin

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6
Q

List some NSAIDs

A

Ibuprofen
Diclofenac
Celecoxib
Naproxen

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7
Q

DMARDs are fast-acting drugs. True/False?

A

False

Slow to act - weeks to months

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8
Q

What effect do DMARDs have?

A

Anti-inflammatory but NO DIRECT ANALGESIA

Reduce rate of joint damage

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9
Q

What is the “window of opportunity” for DMARDs and arthritic patients?

A

Start DMARD within 3 months of symptom onset

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10
Q

What are the 2 DMARDs of choice?

A

Methotrexate

Sulfasalazine

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11
Q

What is the supposed mode of action of methotrexate?

A

Folate antagonist

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12
Q

Methotrexate is teratogenic. What implication does this have?

A

Male and females must stop drug 3 months prior to conception of child

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13
Q

Does hydroxychloroquine have effect on joint damage?

A

No

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14
Q

What is the main anti-TNF drug?

A

Infliximab

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15
Q

Are anti-TNF drugs more effective than DMARDs?

A

Yes

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16
Q

What is the strict criteria for allowing use of anti-TNF?

A

Unresponsive to DMARDs

Scoring: count tender joints + rate activity of disease + check CRP

17
Q

People on anti-TNF drugs must show response to allow continuation of the drug. True/False?

A

True

18
Q

What drugs are given in acute gout?

A

Colchicine (diarrhoea, vomiting)
NSAID
Steroid

19
Q

What is the main drug for gout treatment given following an acute attack?

A

Allopurinol

20
Q

Which enzyme does allopurinol inhibit?

A

Xanthine oxidase to prevent uric acid production

21
Q

Allopurinol should be prescribed in acute gout attack. True/False?

A

False

Can flareup acute gout

22
Q

What is the alternative to allopurinol?

A

Febuxostat

2MB Musculoskeletal (19 decks)

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