Salivary Glands Flashcards Preview

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Flashcards in Salivary Glands Deck (11)
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1
Q

Concentrations in salvia

A

Lower Na, Cl, higher K and HCo3

Hypotonic and alkaline

2
Q

Kallikrein

A

Released by slaivary

Causes breakdwon of kininogen into bradykinin…this causes local vasodilation and inc blood flow to actively secreting gland - just in time delivery

3
Q

Name the glands and how they differ

A

Slightly acidic at rest…basic at high flow

ALWAYS hypotonic but less so at high flow rate

Partoid - serous and amylase (ptyalin)…accounts for 25% at rest but 70% during stimulation

Submandibular - both serous and mucous and majorty of rest

Sublingual - mucus and 5%

Buccal

4
Q

Fxns of saliva

A
Lubrcation
Amylase - pH 4-11
Oral hygeine
Taste
Breakdwon of things
5
Q

Formation of secretions

A

Primary secretion is ultrafiltrate of plasma that is then modified in order to change concetrations

6
Q

Process of formation in mroe detail

A

Need very high blodo flow…first to ducts and then acini

Acinar cells secrete salivary alpha amylase and lingual lipase

Duct cells modify the concentrations
Na-K exchangfe
HCO3-Cl exhcnage

Aldosterone will inc Na/K exchange

Faster flow rates lead to less complete modifcation

7
Q

Duct lumen

Basolateral lumen

A

Cl-HCO3 exchanger
Cl channel
Na channnel
K channel

HCO3/Na uniporter
Cl channel
Na/K atpase

8
Q

Concentrations and how they change with flow

A

K will go down as flow increases

The rest will continue to go up

9
Q

Regulation of salivary glands

A

No classic GI homronal control but Na changed by ADH and alsodsterone

ANS - NTS and superior and inferoir salivary nuceli

PNS - 7 and 9 CN…cholinergic
SNS - inc in salivation - mostly mucous - Beta adrenergci

Cellular - inc cAMP

10
Q

Dysfunction

A

Siallorhea - rabies
Xerostomia - dry motuh
inflammation - mumps…pain with sretching of capsule with mechanisreceptors

11
Q

Pathway for salivation neural

A

Salivary nucleus in the medulla to

Otic - to parotid

Submandiular - to submandibular