Sarah Bailey HPA axis Flashcards Preview

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Flashcards in Sarah Bailey HPA axis Deck (14)
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1
Q

Mifepristone is a GR antagonist at high doses and was reported to relieve psychotic and depressive symptoms of cushings patients

A

Van der lely 1991

2
Q

Mifepristone decreased immobility time in the forced swim test in mice studies

A

Wulsin et al 2010

3
Q

Elevated cortisol is a consistent feature of major depressive disorder

A

Kathol et al 1989

4
Q

Psychotic major depressive patients demonstrate significant elevation in HPA activity due to impaired negative feedback demonstrated in the dexamethasone test

A

Schatzberg 2015

5
Q

Antidepressant treatments result in reduced CRF in the CSF of healthy and depressed patients

A

Hernando 2015

6
Q

Psychotic major depressive patients demonstrate significant impairment in cognition, high cortisol levels correlate with a number of cognitive deficits

A

Schatzberg 2015

7
Q

Depressed patients showed increased levels of CRF in the CSF and increased levels of CRF mRNA expression in the PVN compared to controls

A

?

8
Q

Psychological stress is an important trigger in the development of depression and MDD is associated with an altered ability to adapt to a stressful stimulus

A

Post 1992

9
Q

Ketoconazole and metyrapone resulted in an improvement of depressive symptoms in the majority of patients

A

Murphy 1997

10
Q

Metyrapone has been shown to augment the effects of imipramine in the forced swim test in rats

A

Rogoz et al 2005

11
Q

Over production of CRF in transgenic mice increases anxiety related behaviour

A

Stenzel poore et al 1994

12
Q

Increased CRF in depressed patients, direct injection of CRF increases anxiety, antisense strategies to knockdown CRF reduced anxiety

A

Banki et al 1992

13
Q

R121919 is a CRFR1 antagonist that had good solubility and crossed BBB and improved anxiety and depression states in clinical trials but was stopped due to hepatotoxicty

A

Zobel et al 2000

14
Q

Downregulation of CRF receptors in suicide victims

A

Merali et al 2004