Flashcards in Sarcoma Deck (11)
desmin is a marker for
sarcomas are what percent of adult and pediatric tumors?
s100 antigen suggests:
clear cell carcinoma
neural sheath tumors
Potential molecular markers of sarcoma?
numerous well described chromosomal translocations. Think T11:22 in Ewings
SMAC meta-analysis of adjuvant therapy for sarcoma?
Significant local RFS, distant RFS, overall RFS, but not for overall survival (HR 0.89 CI 0.76-1.03)
More benefit for trunkal/limb sarcomas where DOX had 7% absolute overall survival benefit at 10 years.
Response rate of metastatic STS to single agent chemo
20% for doxorubicin, epirubicin and ifosfamide
most chemo-sensitive subtypes of STS?
Synovial sarcomas and myxoid/round cell liposarcomas
Do GISTs respond to standard chemotherapy?
Additional class of chemo angiosarcomas are sensitive to?
taxanes (paclitaxel) but unclear if this is superior to doxorubicin/ifosfamide.
Potential first line targeted therapy for STS (combined with Dox)
Olaratumab - PDGFR-alpha blocker.
FDA approved 1st line after PHASE II trial. (26.5 v 14.7 mo OS and allowed crossover)
Phase III is Announce - completes in 2020