Seronegative Inflammatory Arthropathies Flashcards Preview

MSK- Rheumatology > Seronegative Inflammatory Arthropathies > Flashcards

Flashcards in Seronegative Inflammatory Arthropathies Deck (23)
Loading flashcards...
1
Q

What are the four types of seronegative inflammatory arthropathies?

A

Ankylosing spondylitis

Psoriatic arthritis

Enteropathic arthritis

Reactive arthritis

2
Q

What blood test is usually positive in Seronegative inflammatory arthropathies?

A

HLA-B27

3
Q

What does HLA-B27 mean?

A

Human leukocyte antigen b27

4
Q

What is important to remember about HLA-B27

A

Only a minority of HLA-B27 positive patients develope spondyloarthritis

5
Q

What is Ankylosing Spondylitis?

A

Chronic inflammatory disease of the spine and sacro-illiac joints which can lead to eventual fusion of joints

6
Q

Who gets ankylosing spondylitis?

A

Males betweem the ages of 20-40

7
Q

What test can measure spine flexion?

A

Schober’s test

8
Q

How do you preform Shobbers test?

A

Measure 10 cm above and 5cm below the posterior superior illiac crest.

When they bend over this should extend to 20cm

9
Q

Which non Joint symptoms are found in ankylosing spondylitis?

A

Uveitis

Aortitis

Pulmonary fibrosis

amyloidosis

10
Q

What is amyloidosis?

A

deposistion of abnormal protiens around the body

11
Q

What would you find in an Xray of a person with ankylosing spondylitis?

A

Sclerosis and fusion of sacroilliac joints

Bony spurs from the vertable bodies known as syndesmophytes

Fusion of intervertebral discs resulting in bamboo spine

12
Q

What percentage of people with ankylosing spondylitis are HLA-B27 positive?

A

90%

13
Q

What are the treatment options of Ankylosing Spondylitis?

A

Phsyio

NSAIDs

Anti-TNF

DMARDs dont work for spinal disease

14
Q

What % of people with psoriasis also have psoriatic arthritis?

A

30%

15
Q

What do you find in the nails of people with psoriatic arthritis?

A

Pitting and onycholysis?

16
Q

What is onycholiysis?

A

Lifting of the nail from its nail bed

17
Q

What is the treatment plan for psoriatic arthritis?

A

Same as RA

DMARDs

Anti-TNF

18
Q

What is Enteropathic arthritis?

A

Inflammatory arthritis affecting peripheral joints and sometimes spine which is associated with IBD

19
Q

How do you treat enteropathic arthritis?

A

Usually you find a drug that can treat the IBD and the arthritis at the same time

20
Q

What is Reactive Arthritis?

A

Arthritis in response to infection of another part of the body

21
Q

What infections usually cause reactive arthritis?

A

Urinary tract infections

22
Q

What organsisms usually cause reactive arthritis?

A

Chlamydia

Neisseria

Salmonella
Camplyobacter

23
Q

What is Reiter’s syndrome?

A

Triad of

Reactive arthritis

Urethritis

Uveitis