SKin Intro: What the skin does Flashcards

1
Q

Predominant role of the epiderimis

A

Barrier

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2
Q

Predominant role of the dermis

A

Structural and nutritional support

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3
Q

What are autoimmune bullous diseases

A

Disorders of epidermal adhesion or cohesion mediated by autoantibodies to the skin adhesion molecules.
Characterized by large blisters

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4
Q

What is the purpose of a desmosome

A

Connects Keratinocytes to each other

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5
Q

What is the purpose of a hemidesmosome>

A

Connect keratinocytes to the basement membrane

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6
Q

Anti-hemidesmosome autoantibodies cause

A

Bulous pemphigoid….black guy with large skin blisters

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7
Q

Anti-desmosome autoantibodies cause

A

Pemphigus vulgaris

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8
Q

Hypohidrotic ectodermal dysplasia

A

Michael Berryman has this disease. abnormal hair folicles, sweat glands, teeth, fingernails. People that suffer from this disease cannot regulate their body temperature well and are extremely sensitive to heat.

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9
Q

Is Hypohydrotic ectodermal dysplasia genetic?

A

Yes

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10
Q

What is the gene mutation in hypohydrotic ectodermal dysplasia

A

Mutations in the EDAR gene which codes for the ectodysplasin A receptor. This protein is critical for proper interactionb between the developing ectoderm and mesoderm

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11
Q

Raynaud’s phenomenon

A

Chronic episodic attacks of digital ischemia provoked by the cold. It is very painful and may be associated with underlying autoimmune disease

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12
Q

Sensory nerve dysfunction may result in?

A

Itch, dysesthetic pain/burning (feels like acid under the skin), hyperesthesia

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13
Q

What is melanin

A

A dark pigment that helps protect against UV damage

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