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Flashcards in Stuff Deck (6)
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1
Q

What are the names of the bonds in the backbone chain of a protein?

A

Psi (ψ) Cα - C bond

Phi (φ) Cα - N bond

2
Q

What AA are good/bad at forming α-helices?

A

Small, hydrophobic residues like Ala and Leu are strong helix formers
Helix breakers - Pro (rotation around N-Cα is impossible), Gly (tiny R group supports other conformations)

3
Q

What is the structure of collagen?

A

Gly - X - Y repeating sequence
Interactions between chains stabilised by H bonds
Triple helical arrangement of collagen chains form a collagen molecule
These molecules are cross-linked covalently to form collagen fibrils
These fibrils look striated if negatively stained, as the regions with no gaps don’t stain as much as the regions with gaps

4
Q

What is a motif?

A

A folding pattern containing 1 or more elements of secondary structure

5
Q

What is a domain?

A

A part of the polypeptide chain that folds into a distinct shape, often has a specific functional role

6
Q

What is the name for inheritance only exhibited in males, when there is just one allele of a gene on the X chromosome?

A

Hemizygous