Systemic Autoimmune Diseases--Nelson Flashcards Preview

IHO Wk 5 > Systemic Autoimmune Diseases--Nelson > Flashcards

Flashcards in Systemic Autoimmune Diseases--Nelson Deck (18)
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1
Q

What does it mean to be immune priviledged?

A

hidden from immune system

(testes, eye, etc.)

2
Q

Two components of autimmune diseases

A

genetic suceptibility + exposure

3
Q

Untreated autimmune diseases become

A

progressive

waxing and waning but slowly progressive

4
Q

SLE pathology

A

type III hypersensitivity component

immune complexes–>binding to tissues–>lumpy deposition

type II hypersensitivity component

result of antibodies against blood components

5
Q

Antiphospholipid antibodies in SLE

A

prolonged PTT

but: hypercoagulable state

6
Q

Where does SLE normally manifest

A

kidneys: proteinuria, cellular casts, lupus nephitis

skin: malor rash, photosensitivity

joints: non-erosive small joint involvement

heme: cytopenias

7
Q

Antibodies against this in RA

A

citrullinated proteins/peptides

8
Q

Rheumatoid nodules

A

areas with central fibirinoid necorsis surrounded by a plisade of macrophages and scattered chronic inflammatory cells

9
Q

Sjogren syndrom pathology

A

autoimmune destruction of lacrimal and salivary glands

10
Q

SS-A and SS-B antibodies seen in which disease

A

Sjogren’s

11
Q

Sjogren’s has what antibodies?

A

SS-A and SS-B

12
Q

Sjogren maligancy risk

A

marginal zone lymphoma

13
Q

Antibodies in scleroderma

A

Scl-70 (DNA Topo-I)

14
Q

Scleroderma

A

chronic inflammaiton of small blood vessels + progressive interstitial and pervascular fibrosis of skin and other organs

15
Q

Diffuse scleroderm

A

widespread, rapid, early visceral involvement

16
Q

Limited scleroderma

A

only skin

17
Q

CREST syndrom

A

scleroderma

calcinosis, Raynaud’s, esphageal dysmotility, sclerodactylyly, telangetasia

18
Q

Anti-Jo1 antibodies

A

polymyositis