Systemic Lupus Erythematosus Therapeutics Flashcards Preview

Pharmacy > Systemic Lupus Erythematosus Therapeutics > Flashcards

Flashcards in Systemic Lupus Erythematosus Therapeutics Deck (7)
Loading flashcards...
0
Q

Cutaneous, joint SLE

A

Anti inflammatory dose of NSAIDs
Hydroxychloroquine

Warfarin for vascular occlusions

1
Q

SLE

A

Prevalent in women

Treatment depends on organ affected

2
Q

Treatment of thrombocytopenia and hemolytic anemia

A

Glucocorticosteroids

If refractory
IGG- collection of population antibodies

3
Q

SLE lupus nephritis

A

Monitor creatinine and clearance

Mild-mod: prednisone + azathioprine

Severe IV cyclophosphamide (pulse monthly)

Mycophenolate has less side effects in long term treatment

Tacrolimus if refractory

4
Q

Neuropsychiatric SLE

A

Prednisone + oral cyclophosphamide
Or IV cyclophosphamide

Rituximab if refractory

5
Q

Gout and hyperuricemia (high uric acid in blood) UA>7

A

Urate crystals in synovial of joint
Under secretion of uric acid in the kidney

Inhibition if tubular secretion may be due to alcohol, aspirin, thiazides

Dehydration may result in acute attack

6
Q

Treatment for gout/hyperuricemia

A

Colchicine - prophylaxis&acute
Prednisone-acute
Pegloticase-acute

Allopurinol, febuxostat - inhibit xanthine oxidase metabolism to uric acid