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PH 152 > Systemic Mycoses > Flashcards

Systemic Mycoses Flashcards

1
Q

Etiologic agents of systemic mycoses are ___ fungi
A. unimorphic
B. dimorphic
C. multimorphic

A

B

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2
Q

reproductive pattern of molds

A

sporulation

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3
Q

possible causative agents of Valley Fever

A

Coccidioides immitis and Coccidioides posadasii

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4
Q

gross morphology of Coccidioides at Saboraud’s Dextrose Agar

A

White to tan cotton colony

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5
Q

microscopic morphology of Coccidioides at Lactophenol Cotton Blue

A

thick walled barrel shaped arthrospores

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6
Q

microscopic morphology of Coccidioides @ Gomori’s methanamine silver

A

spherules with

endospores (pathognomonic of coccidioidomycosis)

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7
Q

A.Thrives in Dry Soil w/ High carbon and salt content
B.Semi-Arid Relatively Hot Regions
C.Seen in the Philippines

False about Coccidioides

A

C

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8
Q

Pathogenesis of Coccidioides
digging of soil –> aerosol of arthrospores –> inhaled –> become (A) –> (A) produces (B) –> (B) released in lungs

What are (A) and (B), respectively?

A

(A)spherules

(B)endospores

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9
Q 
victims of Coccidioides are either asymptomatic or with \_\_ infection at primary stage
A. cardiac
B. pulmonary
C. gastrointestinal
D. cutaneous
A

B

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10
Q

For pulmonary coccidiomycosis, what is the best specimen to collect?

A

Sputum

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11
Q

microscopic morphology of Coccidioides at KOH/Calcofluor white

A

spherules with endospores

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12
Q

Skin test can be used to diagnose Coccidiomycosis. T or F?

A

T. exact positive result: redness and swelling

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13
Q

Ohio Valley Fever
Darling’s Disease
Reticuloendotheliosis
Cave Disease

These all refer to ___

A

Histoplasmosis

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14
Q

main difference in mycelial & yeast colonies of Histoplasma

A

mycelial: cottony
yeast: waxy

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15
Q

Histoplasma capsulatum , which is of ___ shape, usually inhabits these cells.

A

fish-eye

alveolar macrophages

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16
Q

habitat of Histoplasma capsulatum

A

Moist soil due to high nitrogen content supplemented

with bird/bat guano

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17
Q

infective stage of Histoplasma capsulatum

A

microconidia

18
Q

Primary Acute Pulmonary Disease of Histoplasma produces a lesion quite similar to ___ of primary TB

A

Ghon’s complex

19
Q

hematogenous spread of Histoplasma produces a lesion quite similar to ___ of progressive TB

A

Miliary TB

20
Q

lesions present in African Histoplasmosis: enumerate

A

Mucocutaneous lesions (abscess formation and
ulceration)
Insidious osteolytic lesions in ribs, long bones, and
cranium

21
Q

microscopic exam of Histoplasmosis

A

Broadly attached buds on thick walled yeast cells: broad

base

22
Q

Differentiate Coccidioides fr Histoplasma, in terms of culture.

A

Histoplasma uses Glucose-Cysteine Blood Agar

Coccidioides uses Blood Agar Slants

23
Q

Gilchrist’s disease
Chicago Disease

also known as __

A

Blastomycosis

24
Q

etiologic agent of Blastomycosis

A

Blastomyces dermatitidis

25
Q

Blastomyces microscopic morphology @ LPCB

A

lollipop (very tiny conidia)

26
Q

Blastomyces microscopic morphology @ Gomori’s methanamine silver stain

A

thick walled,

multinucleated, spherical yeast

27
Q

A. Dormant: warm, dry season
B. Growth and sporulation: cold, wet season
C. Dwells in soil with low organic matter

Which is false about Blastomyces?

A

C

high dapat

28
Q

When airborne Blastomyces spores are inhaled by a human, s/he can have what lesions?

A

granulomatous, suppurated lesions

29
Q

clin manif of Cutaneous Blastomycosis

A

painless, raised, verrucous lesions

30
Q

microscopic exam of Blastomyces will show

A

Broadly attached buds on thick walled yeast cells: broad

base

31
Q 
Which is not a valid source of Blastomyces?
A.Sputum
B.Pus
C.Exudates
D.Feces
A

D

32
Q

Serologic tests used to diagnose most, if not all, systemic mycoses - enumerate

A

Immunodiffusion

Complement Fixation Test

33
Q

South American Blastomycosis is also known as ___ / ___

A

Paracoccidioides

Paracoccidioidal Granuloma

34
Q

Etiologic agent of South American Blastomycosis

A

Paracoccidiodes brasilienses

35
Q

microscopic exam of Paracoccidioides brasilienses in Methenamine silver stain

A

appears like a Mariner’s steering wheel

36
Q 
P.brasilienses prefers cool, humid soil. \_\_\_ therefore have occupational risk in acquiring it.
A. Agricultural Workers
B. Nurses
C. Fishermen
D. All of the above
A

A

37
Q

There is no latency period for primary pulmonary infection of P.brasilienses;
granulomatous lesions manifest immediately.

T or F?

A

F

Long latency period: may last for 10-20 years

38
Q

mucocutaneous clinical manifestation of Paracoccidioides brasilienses

A

Painful ulcerated lesion may appear on the tongue,

gums, or palate

39
Q

culture media used in diagnosis of P.brasilienses that is not usually used for diagnosis of Coccidioides, Histoplasma and Blastomycoses

A

Yeast Extract Agar

40
Q

Systemic mycoses are contagious. T or F?

A

F

not contagious

PH 152 (47 decks)

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