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Immuno Exam 2 > T Cells > Flashcards

Flashcards in T Cells Deck (21)
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1
Q

Killer T cells are also called

A

Cytotoxic T cells (CTLs)
CD8+,

Activated by MHC I

2
Q

Helper T cells are

A

CD4+, activated by MHC II

Secretes IL-2, IFN-y, TNF

3
Q

Regulatory T cells are

A

CD4+, keeps immune system from over reacting

Secretes IL-10

4
Q

What do helper and killer T cells need before they can function

A

Activation

5
Q

Helper T cells need

A

APCs

Activated dendritic cell

Activated Macrophage

Activated B cell

6
Q

T cell receptor must recognize

A

Its cognate antigen

7
Q

A co receptor must recognize

A

MHC I,II

8
Q

If a T cells gets ______ and ______ is becomes activated

A

Sees non self, co stimulated

9
Q

when a T cell is anergized it is

A

Inactivated and will eventually die

10
Q

T cells only recognize peptides presented on

A

MHC I or MHC II

11
Q

All TCRs on mature T cells are

A

Identical

Alpha B are tradition and most common 95%

12
Q

CD4 is a _____ signal

A

Help signal MHC II

CD8 is a Kill signal MHC I

13
Q

What has more lipid rafts naive or experienced T cells

A

Experienced because it allows for more signaling molecules

14
Q

Helper T cell CD4 co-receptor attaches to

A

MHC II on the dendritic cell

15
Q

Complete activation of helper T cells takes about

A

4-10 hours

16
Q

Th1 Helper T cells are

A

Viral or bacterial attack, classical cytokines TNF, IFN-y, IL-2

17
Q

Th2 Helper cells is

A

Response to parasitic stack or food contamination

IL-4,5,13

18
Q

Th17 does

A

Fungal attack and extracelluar bacteria

Make TGFB and IL-6

Recruits massive numbers of neutrophils

19
Q

What produces IL-21

A

TFH

20
Q

Helper T cells control the size of the response by dicatating the number of Killer T cells via

A

Cytokines

21
Q

CTL delivers the “package” with

A

Perforin and granzyme B