Killer T cells are also called
Cytotoxic T cells (CTLs)
CD8+,
Activated by MHC I
Helper T cells are
CD4+, activated by MHC II
Secretes IL-2, IFN-y, TNF
Regulatory T cells are
CD4+, keeps immune system from over reacting
Secretes IL-10
What do helper and killer T cells need before they can function
Activation
Helper T cells need
APCs
Activated dendritic cell
Activated Macrophage
Activated B cell
T cell receptor must recognize
Its cognate antigen
A co receptor must recognize
MHC I,II
If a T cells gets ______ and ______ is becomes activated
Sees non self, co stimulated
when a T cell is anergized it is
Inactivated and will eventually die
T cells only recognize peptides presented on
MHC I or MHC II
All TCRs on mature T cells are
Identical
Alpha B are tradition and most common 95%
CD4 is a _____ signal
Help signal MHC II
CD8 is a Kill signal MHC I
What has more lipid rafts naive or experienced T cells
Experienced because it allows for more signaling molecules
Helper T cell CD4 co-receptor attaches to
MHC II on the dendritic cell
Complete activation of helper T cells takes about
4-10 hours
Th1 Helper T cells are
Viral or bacterial attack, classical cytokines TNF, IFN-y, IL-2
Th2 Helper cells is
Response to parasitic stack or food contamination
IL-4,5,13
Th17 does
Fungal attack and extracelluar bacteria
Make TGFB and IL-6
Recruits massive numbers of neutrophils
What produces IL-21
TFH
Helper T cells control the size of the response by dicatating the number of Killer T cells via
Cytokines
CTL delivers the “package” with
Perforin and granzyme B