T2DM drugs Flashcards Preview

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Flashcards in T2DM drugs Deck (18)
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1
Q

What T2DM drugs cause weight gain?

A

Sulphonylurea
Pioglitazone
Insulin

2
Q

What drugs cause weight loss?

A

Metformin
SGLT2 inhibitor
GLP-1 agonist

3
Q

What has a higher efficacy and what is used first, DPP-4 inhibitors or GLP-1 agonists?

A

GLP-1 has higher efficacy

DPP-4 is used first

4
Q

What drugs have cardiovascular benefit?

A

Metformin

SGLT-2 inhibitors

5
Q

What drugs carry hypoglycaemia risk?

A

Sulphonylureas

Insulin

6
Q

What drugs have moderate efficacy?

A

Metformin
SGLT2 inhibitors
DPP-4 inhibitors (low/moderate)
Pioglitazone

7
Q

What drugs have high efficacy?

A

Sulphonylureas
GLP-1 agonists
Insulin

8
Q

What is the main adverse effect of metformin?

A

GI

9
Q

What is the main adverse effect of SUs?

A

Hypoglycaemia

10
Q

What is the main adverse effect of SGLT2 inhibitors?

A

Genital infection

11
Q

What is the main adverse effect with DPP-4 inhibitors?

A

Few (can cause headache)

12
Q

What is the main adverse effects of pioglitazone?

A

Oedema

Fractures

13
Q

When you use insulin in T2DM, is it the same regimen as T1DM?

A

No, use basal to start with.

If need more than that refer to a specialist to add in mealtime insulin.

14
Q

What drugs are oral?

A
Metformin
SUs
SGLT-2 inhibitors
DPP-4 inhibitors
Pioglitazone
15
Q

What drugs are injectable?

A

GLP-1 agonists

Insulin

16
Q

What is the main adverse effect of GLP-1 agonists?

A

Gastrointestinal

17
Q

What drugs can be used in CKD and what is the warnings associated?

A
Metformin (max 2g daily)
SU (careful monitoring)
DPP-4 (reduce dose)
Pioglitazone (dose unchanged)
GLP-1 agonist (dose unchanged)
Insulin (dose unchanged)
18
Q

What drug cannot be used in CKD?

A

SGLT-2 inhibitors