Tetracyclines Flashcards Preview

A - MSRA Drugs [4] > Tetracyclines > Flashcards

Flashcards in Tetracyclines Deck (18)
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1
Q

Give 3 examples of tetracyclines

A
  • Doxycycline
  • Tigecycline
  • Tetracycline
2
Q

What is the mechanism of action of tetracyclines?

A

They bind to the 30s ribosomal subunit to prevent tRNA binding, which inhibits bacterial protein synthesis

3
Q

Are tetracyclines broad or narrow spectrum?

A

Broad

4
Q

What are tetracyclines effective against?

A

Gram +ve and -ve bacteria

5
Q

What are the routes of delivery of tetracyclines?

A

PO

IV

6
Q

What are the indications for tetracyclines?

A
  • Acute exacerbation of COPD
  • Intra-abdominal sepsis
  • Acne
  • Malaria
7
Q

Who are tetracyclines contraindicated in?

A
  • Children under 12

- Pregnant or breastfeeding women

8
Q

Why are tetracyclines contraindicated in children under 12 and pregnant/breastfeeding women?

A

Because they interfere with calcium metabolism

9
Q

Who should tetracyclines be avoided in?

A

Those with hepatic or renal impairment

10
Q

What should be monitored with tetracyclines?

A
  • WCC
  • CRP
  • Patient’s clinical state
11
Q

Why should WCC, CRP, and the patients clinical state be monitored with tetracyclines?

A

To look for signs of improvement

12
Q

What drugs might tetracyclines interact with?

A
  • Warfarin

- Antacids and milk

13
Q

What might happen if warfarin is given with tetracyclines?

A

Increased anticoagulant effect

14
Q

What might happen if warfarin is given with antacids and milk?

A

Reduced tetracycline absorption

15
Q

What are the potential side effects of tetracyclines?

A
  • GI disturbance
  • Tooth staining
  • Hepatotoxicity
  • Teratogenicity
  • Antibiotic associated colitis
  • Headache
  • Visual disturbance
  • Benign intracranial hypertension
  • Bulging fontanelles in infants
16
Q

What patient counselling is required with tetracyclines?

A
  • Complete antibiotic course
  • Stained teeth
  • Milk and antacids
17
Q

What counselling is required regarding stained teeth with tetracyclines?

A

Warn that the drug can cause dental staining , and should be avoided in children

18
Q

What counselling is required regarding milk and antacids and tetracyclines?

A

Inform patients not to take tetracyclines at the same time as taking antacids or drinking milk