Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine Flashcards Preview

(Week 3) Foundations of Medicine > Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine > Flashcards

Flashcards in Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine Deck (11)
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1
Q

Folate deficiency before and during pregnancy is associated with neural tube defects such as…

A

Spina Bifida

2
Q

An inherited mutation in the proton coupled folate transporter (PCFT; gene SCL46A1) causes a functional folate deficiency despite adequate folate in the diet. With what disease is this associated?

A

Hereditary folate malabsorption

3
Q

Where does folate go when you have too much in the body?

A

It’s stored in the bile ducts

4
Q

What is the main common result of folate deficiency?

A

Megaloblastic anemia: large red blood cells.

5
Q

Dihydrofolate reductase carries out how many reactions to reach tetrahydrofolate?

A

Two, both add 2 H each time.

6
Q

What drugs target dihydrofolate reductase in humans?

A

Methotrexate (for use in cancer and rheumatoid arthritis)

7
Q

Between 5-Formyl THF, 5-Forminmino THF, and 5-Methyl THF, which is most oxidized, which is most reduced and which is the intermediate?

A

5-Formyl THF: Most ox.
5-Forminmino THF: intermediate
5-Methyl THF: Most reduced

8
Q

In tryptophans processing, it creates what important molecule for folate mechanisms?

A

Formate

9
Q

Which step in 5- methyl THF synthesis is irreversible?

A

5,10 Methylene THF –> 5-Methyl THF

10
Q

When histidine donates a C to THF, what is the intermediate and product?

A
Intermediate = 5-Formino TH (FIGLU)
Product = 5,10 Methenyl THF
11
Q

Serine is the most important C donor to THF because it contribute the most C’s out of any other donors (T/F)

A

T