The Rest of the DNA Viruses

Question 0

What can POXviridae cause?

Answer 0

1. Smallpox

2. Molluscum contagiosum

Question 1

What is the morphology of POXviridae?

Answer 1

1. Complex coat
2. Double-stranded linear DNA
3. The only DNA virus to replicate in cytoplasm

Question 2

What happens in smallpox?

Answer 2

Skin lesions and death - this disease has been eradicated from the earth! :)

Question 3

What happens in molluscum contagiosum?

Answer 3

Small white bumps with a central dimple (like a wart). Often found in the genital region.

Question 4

What is useful to keep in mind about POX-viridae?

Answer 4

1. No animal reservoirs

2. Codes for DNA and RNA polymerases.

Question 5

What is the morphology of PAPOVAviridae?

Answer 5

1. Naked icosahedral
2. Double-stranded circular DNA
3. Replicates in nucleus

Question 6

What are the 3 main pathogenic PAPOVAviridae?

Answer 6

1. HPV
2. BK polyomavirus
3. JC polyomavirus

Question 7

What can HPV cause?

Answer 7

1. Common warts - types 1,2,4,7.
2. Genital warts - types 6,11,16,18 + others.
3. Laryngeal warts - types 6,11.
4. Cervical cancer - types 16,18.

Question 8

What does BK polyomavirus cause?

Answer 8

1. Kidney disease in renal transplant patients.

2. Hemorrhagic cystitis in bone marrow transplant patients, and mild respiratory illness in children.

Question 9

What can JC polyomavirus cause?

Answer 9

Progressive multifocal leukoencephalopathy, characterized by degenerative CNS white matter disease.

Question 10

What are the main methods of wart removal?

Answer 10

1. Liquid nitrogen (freeze them off) - best method.
2. Surgical
3. Electrosurgery (laser ablation)
4. Podophyllin - for genital warts.

Question 11

What is useful to keep in mind about warts?

Answer 11

1. Many warts resolve spontaneously in 1-2 years.

2. Relapses are common after treatment, because HPV DNA is found in normal appearing tissue around the wart.

Question 12

What is interesting to remember about PAPOVAviridae?

Answer 12

Second smallest DNA virus.

Question 13

What is the morphology of ADENOviridae?

Answer 13

1. Naked icosahedral
2. Double-stranded linear DNA
3. Replicates in nucleus

Question 14

What can ADENOviridae cause?

Answer 14

1. Childhood upper respiratory tract infections (rhinitis, sore throat, fever, conjunctivitis).
2. Epidemic keratoconjunctivitis (pink eye).
3. Epidemic diarrheal illness in infants and children.

Question 15

What is important to remember about the problems caused by ADENOviruses?

Answer 15

They are self limited.

Question 16

What is the morphology of PARVOviridae strain B19?

Answer 16

1. Naked icosahedral
2. The only single stranded linear DNA virus (negative stranded).
3. Replicates in nucleus

Question 17

What can PARVOviridae strain B19 cause?

Answer 17

1. Erythema infectiosum (5th disease)

2. Transient aplastic anemia crisis

Question 18

What happens in erythema infectiosum?

Answer 18

Affects children between ages 4-12.
A. Fever
B. “Slapped cheek” rash

Question 19

What is useful to remember about PARVOviridae strain B19?

Answer 19

1. Smallest DNA virus
2. Illness is selflimited
3. IV immunoglobulin can be used in aplastic crisis