Therapeutic Proteins

Question 1

Abbreviation for humanized source

Answer 1

Zu

Question 2

Name 3 disadvantages of cytokine treatments

Answer 2

1. Short t1/2
2. Potent
3. Compliacated cascade = less predictibility

Question 3

Nomenclature order of Therapeutic proteins

Answer 3

[Drug Company Choice] [target][source] MAB

Question 4

2 strategies of antibody therapy?

Answer 4

1. inhibit protein function/block receptor

2. recruit immune system to attack targetq

Question 5

Advantage of Peg-ylated proteins

Answer 5

Longer half life and mask protein from immune system

Question 6

Describe Hypersensitivity I

Answer 6

Immediate and gets worse with repeated administration

Question 7

Describe Type III Hypersensitivity

Answer 7

Slow response and with repeated exposure response lessens

Question 8

List side effects of antibody treatment

Answer 8

Type III Hypersensitivity
HAMA response
Serum Sickness
Infusion reaction
Cytokine Release Syndrome

Question 9

This Protein has the shortest half-life of all therapeutic proteins

Answer 9

TNF

Question 10

Most important feature in antibody therapy

Answer 10

Specificity

Question 11

Which antibodies stimulate RBC prodution

Answer 11

Darbepoeitin
Erythro
MPEG-e

Question 12

Which hematopoetic agents can cause A-fib?

Answer 12

Il-11

Romiplastin

Question 13

Describe Sagramostim

Answer 13

Myeloid stimulus which causes capillary leak, eduema and stimulates granulocytes

Question 14

This drug stimulates production fo neutrophils

Answer 14

Filgrastim (G-CSF)

PEF-filgrastim`