Therapeutic Proteins Flashcards Preview

IHO > Therapeutic Proteins > Flashcards

Flashcards in Therapeutic Proteins Deck (14)
Loading flashcards...
1
Q

Abbreviation for humanized source

A

Zu

2
Q

Name 3 disadvantages of cytokine treatments

A
  1. Short t1/2
  2. Potent
  3. Compliacated cascade = less predictibility
3
Q

Nomenclature order of Therapeutic proteins

A

[Drug Company Choice] [target][source] MAB

4
Q

2 strategies of antibody therapy?

A
  1. inhibit protein function/block receptor

2. recruit immune system to attack targetq

5
Q

Advantage of Peg-ylated proteins

A

Longer half life and mask protein from immune system

6
Q

Describe Hypersensitivity I

A

Immediate and gets worse with repeated administration

7
Q

Describe Type III Hypersensitivity

A

Slow response and with repeated exposure response lessens

8
Q

List side effects of antibody treatment

A
Type III Hypersensitivity
HAMA response
Serum Sickness
Infusion reaction
Cytokine Release Syndrome
9
Q

This Protein has the shortest half-life of all therapeutic proteins

A

TNF

10
Q

Most important feature in antibody therapy

A

Specificity

11
Q

Which antibodies stimulate RBC prodution

A

Darbepoeitin
Erythro
MPEG-e

12
Q

Which hematopoetic agents can cause A-fib?

A

Il-11

Romiplastin

13
Q

Describe Sagramostim

A

Myeloid stimulus which causes capillary leak, eduema and stimulates granulocytes

14
Q

This drug stimulates production fo neutrophils

A

Filgrastim (G-CSF)

PEF-filgrastim`