Thurs Wk 3 Infectious Dz 4 Flashcards Preview

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Flashcards in Thurs Wk 3 Infectious Dz 4 Deck (9)
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1
Q

pt w __ deficits get recurrent Neisseria infections
forms pore leading to __ disturbances, inflow of water and cell __
N men presents w fever, chills, __ skin rash small vessel vasculitis on palms, soles
leads to __ shock w out tx

pts who produce too much __ can also have recurrent neisseria infections
IgA blocks __/__ from activating complement, thus no bacteriocidal effect

Fusion inhib E binds to HR1 of gp41 to stop cell fusion

A
MAC
electrolyte
lysis
petechial
septic

IgA
IgM/IgG

Enfuviritide

2
Q

NNRTI are __ RT inhibs
NRTI are __ RT inhibs

Maraviroc allosterically blocks gp120 from interacting w ___

S__ is nonlactose fermenting, oxidase neg, motile gram neg
has Vi antigen as __ to prevent opsonization
sickling of __ vasculature leads to necrosis w potential for mucosal __
this seeds bone and leads to __

Staph aureus osteomyelitis is caused by adhesion to __

A

allosteric
competitive

CCR5

salmonella
capsule
intestines
breakdown
necrosis

collagen

3
Q

Acyclovir is excreted into urine via glomerular __ and tubular secretion
when conc exceeds solubility, crystallization/crystalluria and __ occur
prevent by __ dose and ensuring adequate hydration

Protein A is virulence factor of outer __ layer in Staph aureus
binds to __ portion of IgG preventing complement activation

Parvo presents w acute symmetric transient __ of joints in adults
can interrupt __ w profound anemia and CHF in fetuses
leads to pleural/pericardial __ and ascites
known as fetal __

A

filtration
damage
dec

peptidoglycan
Fc

arthralgias
erythropoeisis
effusion
hydrops

4
Q

TORCH
Toxo is caused by obligate intracellular __
see C, IC __ and hydroceph

ZVZ presents w limb __ and cutaneous scarring, C and chorioretinitis

Syphillis presents w H__ and skeletal abnorms

Rubella is enveloped __ virus
__ deafness, cataracts, __ rash, PDA and HSM

CMV causes D_ and __ calcifications w jaundice, chorioretinitis

HSV can cause cutaneous __/__ and scarring

A

protozoa
chorioretinitis, calcifications

hypoplasia, cataracts

HSM

ssRNA
sensorineural, blueberry muffin

Deafness, paraventriclar

vesicles, lesions

5
Q

polyprotein precursors are encoded by G/P/E genes
only __ is glycoslyated to gp160
this is cleaved to gp120 and __
gp120 mediates viral attachment by binding __ of susceptible cells
gp41 anchors __ through interacts aiding fusion

RT is incorporated into __ virion and cleaved into viral enzymes during maturation

Chancroid has gram stain described as __ chain

MRSA is freq carried in __

A
gag, pol, env
env
gp41
CD4
gp120

mature

school of fish

anterior nares

6
Q

N men is commonly transmitted via __
thus, close contacts need __
can use R__ which enters all body comparments
or C/C

Penicillin/cephalosporin bind __ to PBP such as transpeptidase

growth of vegetative organisms results in characteristic \_\_ wound w central necrosis and black eschar in B anthracis
spreads via \_\_ to blood and multiplies
C\_\_ is most common form
transmitted via \_\_ or bioterrorism
Pulm form is will \_\_ the pt
A

respiratory droplets
rifampin
Cipro/Cextriaxone

irreversibly

edematous
lymphatics
cutaneous
animals
kill
7
Q

in prokaryotes, 30s ribosomal subunit scans for __ sequence and recognizes AUG n formylmethionine tRNA
energy provided by __ to bring 50S in

drugs that bind to 30s cause genetic code __
initial n-formylmethionine binds at __ site of ribosome

Always use AG alongside bacterial __ inhibitor to allow for entry

Vancomycin can also cause O__
inhibit peptidoglycan __

A

Shine delgarno
GTP

misreading
P

cell wall

ototoxicity
synthesis

8
Q

both Mycoplasma/Chlamidophila pna have __ bilayer membrane

dx gonorrhea w __ test
uses male __ or female urine, V__ or endocervical secretion

untx gonorrhea can progress to P/E

__ may have forchhemier spots on soft palate

A

phospholipid

NAAT
urine
vaginal

prostatitis, epidydimitis

rubella

9
Q

Roseola infantum caused by __
children < __ yo
3-5 days of high fever w __ maculopapular rash
starts on __ and spreads to face/extremities

A

HHV6
2
blanching
trunk