Topic 50 - Neurohormonal regulation of food intake and gastrintestinal tract Flashcards

1
Q

Words to include in regulation of food intake

A
  • Hunger
  • Satiety
  • Appetite
  • Lateral nucleus of hypothalamus
    • Gluttony (hyperphagia)
    • Aphagia
  • Ventromedial nucleus of hypothalamus
  • Amygdale
  • Prefrontal cortex

Mediators decreasing food intake:

  • Acetylcholine
  • Serotonin
  • Cholecystokinin (CCK)
  • Gulcagon
  • Somatosin
  • VIP
  • Neurotensin

Mediators increasing food intake:

  • Hypothalamic neuropeptide Y (NPY)
  • Opoid peptides
  • Dopamine
  • GABA
  • Leptin
  • Regulatory signals:*
  • Glucostatic
  • Aminostatic
  • Volatile fatty acid effect
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2
Q

Words to include in neuro-hormonal regulation of the GI-tract

A
  • Passing
  • Mixing
  • Mincing
  • CNS
  • Local regulation
  • Chewing
  • Swallowing
  • Salivary secretion
  • Defecation
  • Stomach secretion, stomach motility
  • Pancreatic juice secretion, gall bladder secretion
  • Small intestine motility, large intestine motlilty
  • Intestinal juice production
  • Neural regulation*
  • Extrinsic neural regulation
    • Hyperpolarization
      • sympathetic
        • Post ganglionic
        • Noradrenaline
    • Parasympathetic
      • Pre ganglionic
  • Intrinsic neural regulation
    • Plexus myentericus
    • Plexus submucosus
    • GI secretion
    • Peristalsis
    • Mingling
    • Local inhibition
    • Absorption
    • Intensity and frequency of contraction
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3
Q

What should be included in the essay?

A
  1. Regulation of food intake
    • Figure
    • Hunger, satiety, appetite
  2. Hunger theories
    • Regulating factors for the center for satiety
    • Mediators decreasing and increasing food intake
  3. Regulatory signals
  4. Effects of GI-tract
  5. Neuro-hormonal regulation of the GI-tract
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4
Q

Give the figure of the regulation of food intake

A
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5
Q

Define hunger

A
  • Lateral nucleus of hypothalamus
  • Stimulation of the nuclei causes:
    • Gluttony (hyperphagia)
      • Abnormally increased appetite
  • Lesion of the nuclei causes:
    • Aphagia
      • Loss of the ability to swallow
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6
Q

Define satiety

A
  • Ventromedial nucleus
  • Lesion → hyperphagia
  • Stimulation → aphagia
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7
Q

Define appetite

A
  • Amygdale and prefrontal cortex
  • Hunger complex directing food selection
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8
Q

What is the center for satiety regulated by

A

Factors from the outside- or inside environment

  • Outside factors:
    • Densitry of the population
    • Behavior of the animal (hierarchy)
    • Temperature
    • Humidity
    • Period and daily rhythm of light
    • Characteristics of fodder
  • Inner factors:
    • Fullness of the stomach
    • Hormones
    • Different materials of intermediary metabolism
    • Herbivores: catabolic products of cellulose
    • Car: amino-acid balance
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9
Q

Give the mediators decreasing food intake

A
  • Acetylcholine
  • Serotonin
  • Cholecystokinin
  • Glucagon
  • Somatosin
  • VIP
  • Neurotensin
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10
Q

Give the mediators increasing food intake

A
  • Hypothalamic neuropeptide Y (NPY)
  • Opioid peptides
  • GABA
  • Dopamine
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11
Q

What is the regulatory factor?

A
  • Leptin
    • Reduces feed uptake when enough reserved have been formed
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12
Q

Give the nutritional regulatory signals

A
  • Glucostatic
    • Increased glucose level → satiety
    • Decreased glucose level → hunger
  • Aminostatic
  • Volatile fatty acid effect
    • Increased free volatile fatty acids in the blood → food intake is decreased or entirely terminates
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13
Q

Give the effects of the GI tract

A
  • Hormonal effects
  • Gastric and intestinal filling
  • Density of the population
  • Hierarchy Hormonal effects on hunger
  • Night-day cycle
  • Temperature
  • Estrogen
  • Volemia
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14
Q

Movement of the alimentary canal

A
  • Passing
  • Mixing
  • Mincing
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15
Q

Neuro-hormonal regulation of the GI-tract

  1. Under CNS control
  2. Under local regulation, but influenced by CNS
A
  1. The initial and terminal tract
  2. Stomach to rectum
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16
Q

Neural regulation

A
  • Extrinsic neural regulation
    • Sympathetic (Postganglionic)
      • Noradrenaline = hyperpolarization, and decreasing resting membrane potential
    • ​​​Parasympathetic (preganglionic)
      • Increases GI motility → causes hyperpolarization of enteral nerve cells
  • Intrinsic neural regulation:
    • Plexus myentericus
      • Efferent neurons of local reflex arches
      • Increases:
        • contraction tone
        • Frequency
        • Intensity
        • Velocity
    • Plexus submucosus
      • Receptors and afferent neurons of local reflex arches
      • Regulates:
        • Peristaltic movements
        • Local secretion of GI juices
        • Absorption