Transplant Immunology Flashcards
Which part of the immune system is specific or non-specific?
Specific
-Adaptive
Non-Specific
-Innate
Exterior defenses of the innate immune system
skin mucus cilia saliva low pH GI tract normal flora
Exterior defenses of the adaptive immune system
NONE
Specificity of Innate Immune System
Limited and Fixed
(Non-specific)
Specificity of Adaptive Immune System
Extensive
Which type of immune system has memory?
Adaptive
Time it takes for each type of immune system to respond
Innate
-hours
Adaptive
-days
Soluble factors of the Innate Immune System
Lysozymes Complement C-Reactive Protein Interferons Antimicrobial Peptides Mannose Binding Lectin
Soluble factors of the Adaptive Immune System
Antibodies
Cytokines
Cell types of the Innate Immune System
Neutrophils Monocytes Macrophages Natural Killer Cells Eosinophils
Cell types of the Adaptive Immune System
T lymphocytes (Tc and Th) B lymphocytes (memory and effector) -aka plasma cells
What does it mean that the innate immune system’s specificity is limited and fixed?
It cannot learn and does not have a memory.
Neutrophil
Granulocyte
- first responder
- small eater (phagocyte)
- esp if coated with IgG
- contain lysosomes
- small eater (phagocyte)
Segs vs Bands
Segs -mature neutrophils -float in blood Bands -immature neutrophils -not in circulation
Left Shift
Shift from Segs to Bands in blood
-indicating neutrophil response to infxn
(usually bacterial)
