Tumor Markers Flashcards Preview

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Flashcards in Tumor Markers Deck (11)
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1
Q

Alkaline phosphatase

A

Metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)

2
Q

alpha-fetoprotein

A

Normally made by fetus. Hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, testicular cancer, mixed germ cell tumor (co-secreted with ß-hCG

3
Q

ß-hCG

A

Hydatidiform moles & Choriocarcinomas (Gestational trophoblastic disease), testicular cancer

Commonly associated w/ pregnancy

4
Q

CA-15-3/CA-27-29

A

Breast cancer

5
Q

CA-19-9

A

Pancreatic adenocarcinoma

6
Q

CA-125

A

Ovarian cancer

7
Q

Calcitonin

A

Medullary thyroid carcinoma

8
Q

CEA

A

Carcinoembryonic antigen. Very nonspecific but produced by ~70% of colorectal & pancreatic cancers; also produced by gastric, breast & medullary thyroid carcinomas

9
Q

PSA

A

Prostate-specific antigen. Used to follow prostate adenocarcinoma. Can also be elevated in BPH & prostatitis. Questionable risk/benefit for screening.

10
Q

S-100

A

Neural crest origin (melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)

11
Q

TRAP

A

Tartrate-Resistant Acid Phosphatase

Hairy cell leukemia: B-cell neoplasm