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Flashcards in Tumor Markers Deck (11)
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1
Q

Alk Phos

A

Metastases to bone, liver, Paget disease of bone, seminoma (placental ALP)

2
Q

alpha fetoprotein

A

normally made by fetus. hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, testicular cancer, mixed germ cell tumor (co-secreted with beta hCG)

3
Q

B-hCG

A

Hydatiform moles and Choriocarcinomas (gestational trophoblastic disease), testicular cancer; Commonly associated with pregnancy

4
Q

CA-15-3/CA-27-29

A

Breast Cancer

5
Q

CA-19-9

A

Pancreatic Adenocarcinoma.

6
Q

CA-125

A

Ovarian cancer

7
Q

Calcitonin

A

Medullary thyroid carcinoma

8
Q

CEA

A

CarcinoEmbryonicAntigen. Very nonspecific but produced by 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and medullary thyroid carcinomas.

9
Q

PSA

A

Prostate-specific antigen. Used to follow prostate adenocarcinoma. Can also be elevated in BPH and prstatitis. questionable risk/benefit for screening.

10
Q

S-100

A

Neural crest origin (melanomas, neural tumors, scwannomas, langerhans cell histiocytosis)

11
Q

TRAP

A

Tartrate-Resistant Acid Phosphatase (TRAP). Hair cell Leukemia (B cell neoplasm). TRAP the hairy animal. Largely replaced by flow cytometry