Tumor Translocations Flashcards Preview

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Flashcards in Tumor Translocations Deck (13)
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1
Q

t(9,22)

A

CML
Bcr-Abl
Constitutive activation of Tyrosine Kinase

2
Q

t(8;14)

A

Burkitt Lymphoma
c-myc activation-
Transcription activator controlling cell proliferation, differentation and apoptosis

3
Q

t(11;14)

A

Mantle Cell Lymphoma

Cyclin D1 activation- progression of G1 to S phase

4
Q

t(14;18)

A

Follicular Lymphoma or DIffuse B cell

Bcl-2 activation-anti-apoptotic (follicular)
Bcl-6 disactivation (Diffuse)

5
Q

t(15;17)

A

M3 subtype of AML

Abnormal retinoic acid receptor that is responsive to Vitamin A

6
Q

t(8;21)

A

AML

Still with Auer Rods

7
Q

t(12,21)

A

Good prognosis T-ALL/B-ALL

8
Q

T(9,22)

A

T-ALL/B-ALL

9
Q

(11;18) (14, 18) or (1:14)

A

Marginal Zone Lymphoma

Upregulation of BCL10 Nf-KB

10
Q

inv16

A

AML

11
Q

deletions of 5q and 7q

A

AML associated with chemotherapy

12
Q

deletion 13q

A

CLL

13
Q

t(11,22)

A

Ewing Sarcoma