Uterine Drugs Flashcards Preview

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Flashcards in Uterine Drugs Deck (15)
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1
Q

Sm muscle contractile pathway

A
Gq-receptor mediated
activation of phospholipase C
IP3 formation
release of calcium
sm muscle contraction
2
Q

Sm muscle relaxation pathway

A
Gs-receptor mediated
adenylyl cyclase activated
cAMP increased
cAMP activates protein kinase A
protein kinase A inactivates myosin light chain kinase
contraction of sm muscle stops
3
Q

Oxytocin receptors in myometrium

A

only present in myometrium during 3rd trimester

4
Q

Oxytocin receptor type

A

Gq coupled receptor

5
Q

Oxytocin
MOA
TU
Tox

A

MOA: bind oxytocin receptors, stimulate uterine contractions
TU: induction of labor, only in 3rd trimester when oxytocin receptors are present in myometrium
Tox: uterine rupture (prior Hx of C-sections), not to be used w/ hypertonic uterine contractions (will not help)

6
Q

Prostaglandin receptors in sm muscle

A

Gq coupled receptors

usually PGE2 or PGF2α

7
Q

Dinoprostone
MOA
TU

A

MOA: PGE2
TU: hydatiform mole

8
Q

Misoprostol
MOA
TU

A

MOA: PGE1
TU: abortifacent, used w/ mifepristone (progesterone receptor antagonist)

9
Q

Dinoprost
MOA
TU

A

MOA: PGF2α
TU:

10
Q

Carboprost
MOA
TU

A

MOA: PGF2α
TU: abortifacent, labor induction

11
Q

Ergonovine
MOA
TU
Tox

A

MOA: α-andrenergic, dopaminergic, 5HT2 receptors, ultimately induces uterine contractions -> blood vessel compression
TU: control post-pardum bleeding
Tox: not used before fetus is delivered

12
Q

Ergotamine
MOA
TU

A

MOA: α-adrenergic, dopaminergic, 5HT2 receptors, ultimately causes cerebral vasoconstriction
TU: migraines

13
Q

Magnesium sulfate
MOA
TU

A

MOA: competes w/ Ca2+ for binding sites in sm muscle cells, prevents sm muscle contraction
TU: prevents seizures associated w/ eclampsia

14
Q

Terbutaline
MOA
TU
Tox

A

MOA: β2 agonist
TU: prevent/stop contractions
Tox: tachycardia (non-selective), pulmonary edema, headaches, hyperglycemia

15
Q

Atosiban
MOA
TU
Tox

A

MOA: oxytocin receptor antagonist
TU: delays labor, rapid onset
Tox: increased fetal mortality