Vagina - Pathoma Flashcards Preview

Hormonal & Reproductive Week 3 - WLB > Vagina - Pathoma > Flashcards

Flashcards in Vagina - Pathoma Deck (14)
Loading flashcards...
1
Q

What type of epithelium lines the vagina?

A

Non-keratinized stratified squamous epithelium

2
Q

What is Adenosis?

A

Focal persistance of columnar epithelium in upper 2/3 of vagina

3
Q

Females exposed to what have an increased incidence of adenosis?

A

DES = diethylstillbesterol

drug used to treat post-menopausal sx and prevention of miscarriage

4
Q

What do you call a malignant proliferation of glands will clear cytoplasm?

A

Clear cell adenocarcinoma

5
Q

How does Clear cell adenocarcinoma develop?

A

Rare complication of DES-associated vaginal adenosis

6
Q

Which patient populations could be exposed to DES and subsequently develop DES complications?

A

DES mom (in the 1960’s) => breast carcinoma

DES daughter => adenosis, Clear cell adenocarcinoma, dysfunctional uterine development

DES son => no complications

7
Q

What do you call a rare, malignant mesenchymal proliferation of immature skeletal muscle in the vagina?

A

Embryonal Rhabdomyosarcoma

variant of Sarcoma botryoides, which means grape-like mass

8
Q

What is the interesting presentation of Embryonal Rhabdomyosarcoma that gets tested on boards?

A

Bleeding and a grape-like mass protruding from the vagina

Affects girls

9
Q

What is the key cell that forms the tumor in Embryonal Rhabdomyosarcoma?

A

Rhabdomyoblast = immature spindle-shaped cells with cytoplasmic cross-striations

10
Q

How do you diagnose Embryonal Rhabdomyosarcoma?

A

Positive IHC stains for desmin and myogenin

11
Q

What is Vaginal Carcinoma usually related to?

A

high-risk HPV (16, 18, 31, 33)

12
Q

What is the precursor lesion in Vaginal Carcinoma?

A

epithelial dysplasia = vaginal intraepithelial neoplasia (VAIN)

13
Q

Which lymph nodes are involved in a cancer from the lower 1/3 of the vagina?

A

inguinal lymph nodes

14
Q

Which lymph nodes are involved in a cancer from the upper 2/3 of the vagina?

A

regional iliac lymph nodes